非糖尿病患者的视网膜病表现是否可作为糖尿病发病的预测因子  

Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes?

作　　者：Wong T. Y. Mohamed Q. Klein R. Couper D. J. 安胜(译) 

机构地区：[1]不详 [2]Centre for Eye Research Australia, 32 Gisborne Street, Vic. 3002, Australia

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期59-59,共1页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Background/aims: Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes,the association of these retinopathy signs and subsequent development of diabetes were examined. Methods: A population based cohort study of 7992 people aged 49-73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively. Results: After a follow up of 3 years,291 (3.6% ) people developed incident diabetes. In the total cohort,retinopathy was not significantly associated with incident diabetes (4.7% v 3.6% ,multivariable adjusted odds ratio (OR) 1.1,95% confidence intervals (CI),0.7 to 1.9). However,among participants with a positive family history of diabetes,retinopathy was associated with incident diabetes (10.4% v 4.8% ,multivariable adjusted OR 2.3,95% CI,1.0 to 5.3). Among participants without a family history of diabetes,retinopathy was not associated with incident diabetes Conclusions: In individuals with a family history of diabetes,retinopathy signs predict subsequent risk of clinical diabetes.Background/aims： Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined. Methods： A population based cohort study of 7992 people aged 49 - 73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively. Results： After a follow up of 3 years, 291 （3. 6% ） people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes （4.7% v 3.6%, multivariable adjusted odds ratio （OR） 1.1, 95% confidence intervals （CI）, 0.7 to 1.9）. However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes（10. 4% v 4.8%, multivariable adjusted OR 2. 3, 95% CI, 1.0 to 5.3） . Among participants without a family history of diabetes, retinopathy was not assoeiated with ineident diabetes Conelusions： In individuals with a family history of diabetes, retinopathy signs prediet subsequent risk of elinieal diabetes.

关 键 词：糖尿病患者 视网膜病 预测因子 发病 葡萄糖代谢障碍 无糖尿病史 糖尿病家族史 队列人群 队列研究 受试者 

分 类 号：R587.1[医药卫生—内分泌] R774.1[医药卫生—内科学]