男性生殖道不同部位支原体感染与不育症相关性研究  

The relationship between mycoplasma infection in different parts of male genitourinary tract and infertility

作　　者：吕伯东[1] 杨克冰[1] 黄以政[1] 黄晓军[1] 胡青[1] 张士更[1] 马寅锋[1] 

机构地区：[1]浙江中医药大学附属第二医院泌尿外科,浙江杭州310005

出　　处：《全科医学临床与教育》2006年第4期291-293,共3页Clinical Education of General Practice

摘　　要：目的研究男性生殖道不同部位支原体感染与不育症之间的关系。方法将81例不育症患者随机分成3组,均分别取尿道分泌物、前列腺液及精液作解脲支原体(ureaplasma urealyticum,UU)培养,比较三种取材部位感染UU后的检出率和三组间上述各项指标的差异性,并将UU阳性患者(共26例)与正常男性组(共30例)作精液常规分析、精浆肉素碱和抗精子抗体(AsAb)等三个项目检测对照。结果三组间比较：尿道分泌物UU的检出率最高,为48．15%；前列腺液检出率为33．33%,精液检出率为14．81%；精液组各个项目比尿道分泌物组和前列腺液组均低下,差异有统计学意义,(P＜0．05)；而另两组比较,差异无统计学意义(P＞0．05)；81例不育患者中有26例UU阳性,占32．09%。与30例正常男性对比,其三个项目指标均低下,差异有统计学意义,(P＜0．01)。结论UU的检出率以取尿道部标本为最高；睾丸、附睾、精囊和输精管部感染UU后可能对不育症的影响最大；解脲支原体感染可能引起精液质量减退、诱发抗精子抗体产生、减少精浆肉毒碱合成,从而导致生育能力下降。Objective To study the relationship between mycoplasma infection in different parts of male genitourinary tract and infertility. Methods Eight one infertile males were divided into 3 groups randomly. Their urethral secretions, prostate fluid and spermatic fluid were collected and made ureaplasma urealyticum（UU） culture. The detective rates of UU in three different parts of male genitourinary txact were compared and the variability of above-mentioned index was also contrasted among the 3 groups. And the semen analysis, carnitin content and antisperm antibody（AsAb） were compared between the infertile men harboring UU（26 cases） and normal fertile men （30 cases） . results ①Comparison among the three different parts：The detective rate of UU in Urethral secretions was 48.15% ,in prostate fluid was 33.33% ,and spermatic fluid was 14.81% ;②All biochemical indicators of spermatic fluid group were distinctly less than that of urethral secretion group and prostate fluid group（ P 〈 0.05） . The difference between the other two groups did not have statistically significance （ P 〉 0.05）.③There were 26 cases of UU in 81 infertile males（32.09% ） . Compared with the 30 cases in the control group, all the indexes of the three items were obviously lower （ P 〈 0.01）. Conclusion Infection of UU in the parts of testicle, epididymis, vesicle and deferent canal affected infertility most; Infection of UU could de- press male reproductive ability by decreasing sperm quality, inducing the production of AsAb, and decreasing the combination of seminal plasma carnitin.

关 键 词：男性生殖道 支原体 不育症 

分 类 号：R698.2[医药卫生—泌尿科学]