THE PREPARATION OF DOXORUBICIN-POLYVINYLPYRROLIDONE-NANOPARTICLES BY INVERSE EMULSION POLYMERIZATION  

作　　者：LV Fengjiao LIN Huaxiang XU Xiaoping CHEN Xiaogeng 

机构地区：[1]School of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China [2]Fujian Provincial Hospital Fuzhou 350000, China

出　　处：《Chinese Journal of Reactive Polymers》2006年第1期76-80,共5页中国反应性高分子（英文版）

基　　金：ScienceandTechnologyMinistryofFujian(2005I010and2001Z046)

摘　　要：Doxorubicin-loaded nanoparticles, using doxorubicin （ADM） as model drug and vinylpyrrolidone as matrix, were prepared by inverse emulsion polymerization in the paper. The nanoparticles were characterized by telescope electron microscopy （TEM）, laser light scattering technique （LLS） and infrared spectrum （IR）. LLS test showed that the optimal prepared ADM-loaded nanoparticles had an average size 18.8nm and a narrow size distribution between 15nm and 32nm, which was consistent with the result obtained by TEM. And 1R results indicated that the nanoparticles consisted of ADM and polyvinylpyrrolidone （PVP）.Doxorubicin-loaded nanoparticles,using doxorubicin(ADM)as model drug and vinylpyrrolidone as matrix,were prepared by inverse emulsion polymerization in the paper.The nanoparticles were characterized by telescope electron microscopy(TEM),laser light scattering technique(LLS)and infrared spectrum(IR).LLS test showed that the optimal prepared ADM-loaded nanoparticles had an average size 18.8nm and a narrow size distribution between 15nm and 32nm,which was consistent with the result obtained by TEM.And IR results indicated that the nanoparticles consisted of ADM and polyvinylpyrrolidone(PVP).

关 键 词：NANOPARTICLES POLYVINYLPYRROLIDONE Inverse emulsion polymerization 

分 类 号：TQ460.6[化学工程—制药化工]