男性急性冠状动脉综合征患者性激素水平与内皮素、血管性假血友病因子改变的关系  

Relationship between sex hormone level and endothelin-1,von Willebrand factor in male patients with acute coronary syndrome

作　　者：张慧敏[1] 张密林[1] 高磊[1] 刘丽[1] 解启莲[1] 赵根[1] 

机构地区：[1]河北医科大学第一医院心内2科,河北石家庄050031

出　　处：《临床荟萃》2006年第15期1075-1077,共3页Clinical Focus

摘　　要：目的探讨性激素水平与血管内皮功能的关系及性激素内环境紊乱在男性急性冠脉综合征(ACS)发生中的作用。方法用放射免疫法和酶联免疫吸附测定(ELISA)法测定了61例男性ACS患者[其中急性心肌梗死(AM I)30例,不稳定型心绞痛(UAP)31例]和30例男性健康志愿者的血清雌二醇(E2)、孕酮(P)和睾酮(T)水平及血浆内皮素(ET-1)、血管性假血友病因子(vWF)水平。结果ACS(AM I和UAP)患者E2、E2/T明显高于正常对照组[E2(125.09±30.60)ng/L和(107.50±38.40)ng/L vs(61.60±44.00)ng/L,E2/T:24.86±12.59和18.23±9.77 vs8.87±8.50,均P<0.01],而T水平明显低于正常对照组(5.71±1.78)μg/L和(6.63±1.98)μg/L vs(9.11±2.26)μg/L,P<0.01),性激素水平失衡(主要表现为E2/T的改变)与血浆ET-1、vWF水平之间存在明显的正相关关系。结论高E2血症及T水平降低在男性ACS的发病中起重要作用。男性ACS性激素水平失衡与内皮功能之间可能存在着密切的联系。Objective To investigate the relationship between sex hormones（SH） and endothelial dysfunction and to explore the mechanism of internal environment disturbance of sex hormones on atherosclerosis and coronary heart disease in male patients with acute coronary syndrome（ACS）. Methods Sixty-one male patients acute myocardial infarction（AMI） 30,unstable angina pectoris（UAP） 31 and 30 healthy volunteers were divided into three groups： AMI group,UAP group and control group. Radioactive-immune method or enzyme-linked immunosorbent assay（ELISA） method was used to measure estrogen（E2 ）, progesterone（P）, testosterone（T）, endothelin-1 （ET-1） and von Willebrand factor（vWF）. Results E2 level of serum was significantly higher [AMI group（125.09±30. 60） ng/L and （UAP group 107. 50±38.40） ng/L vs （61.60±44.00） ng/L,E2/T：（24.86±12. 59）μg/L and （18.23±9.77）μg/L vs （8.87±8.50）μg/L, （ P 〈0. 01）],and T level of serum was significantly lower [5.71±1.78 and 6.63±1.98 vs 9.11±2.26（ P 〈0. 01）] in ACS patients than those in control group. The disturbance of SH was correlated with ET-1 and vWF level of plasma. Conclusion Higher serum E2 level and lower serum T level may be responsible for ACS in great degree. There may be relationship between SH disturbance and endothelial dysfunction.

关 键 词：冠状动脉疾病 性腺甾类激素 内皮缩血管肽1 von WILLEBRAND因子 

分 类 号：R541.4[医药卫生—心血管疾病]