含钙镁D的某壮骨片增加骨密度作用动物实验研究  

Experimental study on the effect of bone-strengthening tablet in strengthening the bone density in animals

作　　者：周月婵[1] 胡怡秀[1] 胡余明[1] 张莹莹[1] 邓彬彬[1] 伍碧珍[1] 

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410005

出　　处：《中国热带医学》2006年第8期1368-1370,共3页China Tropical Medicine

摘　　要：目的探讨以钙、镁、维生素D、大豆异黄酮为主要成分的某壮骨片的增加骨密度作用。方法以0.234g/kg.bw0、.467g/kg.bw、1.401g/kg.bw(相当于人体推荐剂量5、10、30倍)剂量的某壮骨片给大鼠喂饲12wk,测定大鼠身长、股骨重量、股骨钙含量及骨密度等指标。结果实验组大鼠的身长和身长净增加值、股骨中心及远心端的矿物质含量和骨密度、股骨重量、股骨钙含量及总钙量、摄入钙、粪钙和尿钙含量显著高于低钙对照组,钙表观吸收率和存留率显著低于低钙对照组,差异具有显著性(P<0.01或P<0.05)。结论该壮骨片具有增加大鼠骨密度的作用。Objective To expporethe the effect of a bone - strengthening tablet with calcium, magnesium, vitamin D and daidzein as its major components in increasing bone density in animals. Methods Rats were orally given the tablet at doses of 0.234g/kg·bw, 0.467g/kg·bw,1.401g/kg·bw for 12 weeks. The body height, the weight femur, The content of calcium in femur and density of the femur were determined . Results As compared with those in the low - calcium control group, the final body height and the net height increment, the content of mineral substance in the central part and end part of the femur, bone density, bone weight, calcium content in the femur and total calcium amount, calcium ingested, calcium in feces and urine of the rats in the experimental groups were significantly higher （ P 〈 0.01, P 〈 0.05 ）, whereas apparent digestibility and storage rate were significantly lower （ P 〈 0.01, P 〈 0.05）. Conclusion This tablet could increase bone density.

关 键 词：壮骨片 骨密度 动物 

分 类 号：R282.77[医药卫生—中药学]