不孕不育患者与抗精子抗体和抗子宫内膜抗体的相关性分析  

Study on the correlation of infertility with antispermactic antibody and antiendometrial antibody

作　　者：许晓清[1] 吴方贵[1] 邱耀芳[1] 

机构地区：[1]深圳市罗湖区人民医院,广东深圳518001

出　　处：《中国热带医学》2006年第8期1371-1372,共2页China Tropical Medicine

摘　　要：目的探讨抗精子抗体(AsAb)和抗子宫内膜抗体(EMAb)检测在不育不孕症患者中的临床价值。方法应用酶联免疫吸附试验(ELISA法)对1 197例不孕不育者进行了抗精子抗体与抗子宫内膜抗体检测,同时与健康组作对比研究。结果不孕不育组AsAb总阳性检出率为21.7%(260/1 197),男性病例阳性为18.4%(94/511),女性不孕病例检测阳性占24.2%(166/686);健康组AsAb阳性率则为3.6%(2/56),经统计学处理,P<0.01。而686例女性不孕不育中原发组AsAb阳性占24.1%(60/249),继发不孕组占24.3%(106/437);EMAb检测不孕组为9.2%(63/686),原发不孕占7.6%(19/249),继发不孕占10.1%(44/437),健康孕妇组为0(0/28),两组对比P<0.01。结论AsAb和EMAb与不孕(育)密切相关。Objective To explore the clinical value of antisperm antibody （AsAb） and antiendometrial antibody （EMAb） in diagnosis of infertility patients. Methods AsAb and EMAb of 1 197 infertility patients were determined by using ELISA and compared to those of normal controls. Results The total positive rote of AsAb in infertility group was 21.7 % （260/1 197）, the positive rate in male group was18.4% （94/511）, 24.2% （166/686） in female group and 3.6% （2/56） in normal control, showing significant difference （ P 〈 0.01 ）. EMAb in female infertility group was 9.2% （63/686） , the positive rates of AsAb and EMAb in primary infertility patients were 24.1% （60/249） and 7.6% （19/249） and the positive rates of AsAb and EMAb in secondary infertility were 24.3% （106/437） and 10.1% （44/437）, while that in the control was 3.6% （1/28） and 0（0/28）, showing significant difference （ P 〈 0.01 ）. Conclusion AsAb and EMAb were closely associated with infertility.

关 键 词：不孕不育 抗精子抗体 抗子宫内膜抗体 

分 类 号：R711.6[医药卫生—妇产科学]