新生儿筛查TSH切值的应用研究  

The Applying Study on the Neonate Screening TSH Cut-off

作　　者：马妍丽[1] 秦良谊[1] 唐玉娣[1] 刘波[1] 

机构地区：[1]江苏省连云港市第一人民医院新筛中心,222002

出　　处：《中国妇幼保健》2006年第15期2099-2100,共2页Maternal and Child Health Care of China

摘　　要：目的：探讨用新生儿足跟全血血片TSH筛查新生儿先天性甲状腺功能减低症（CH）的切值和监测人群碘营养状况的可能性。方法：用TRFIA法筛查新生儿72h足跟全血血片TSH。结果：正常新生儿TSH频数呈正偏态分布，TSH〉5mU／L比率2．17％，99％分位数为6．89μU／ml，筛查确诊17例CH，其中5例（29．4％）TSH筛查时呈现低值9．11～18．0μU／ml。结论：本地区筛查CH切值以8μU／ml为宜，TRFIA筛查新生儿TSH〉5mU／L比例〈3％可作为人群碘营养状况正常的标志。Objective ： To study the applicability of the CH cut - off by neonatal screening and of the monitoring of peopleg normal nutritional condition （TSH 〉 5mu/L percentage 〈 3% ） . Methods： Screen the TSH of full heel blood of neonate of 72h＇s old by TRFIA method. Results： the TSH frequency of normal neonate shows positively skew distribution （TSH 〉 5mu/L percentage 2. 17% , 99% quartile： 6.89 μU/ml） . 5 samples among 17 samples （29.4%） diagnosed to be CH by screening shows low level 9. 11 - 18.0 μU/ml when being screened. Conclusion： It＇s appropriate to set the CH cut -off of local area at 8 μU/ml TSH 〉 5 mu/L and percentage 〈 3% by TRFIA neonatal screening method can be regarded as people＇s normal iodic nutritional level.

关 键 词：新生儿 先天性甲状腺功能减低症(CH) 促甲状腺素(TSH) 切值 碘营养状况 

分 类 号：R174.1[医药卫生—妇幼卫生保健]