血清抗精子抗体对体外受精及单精子显微注射的影响  

Effect of Anti Sperm Antibody In An In Vitro Fertilization Embryo Transfer Program

作　　者：杨桂艳[1] 董渭盈[1] 杨如春[1] 

机构地区：[1]广东省珠海市妇幼保健院,519000

出　　处：《中国妇幼保健》2006年第15期2103-2105,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨抗精子抗体(AsAb)对常规体外受精(IVF-ET)及卵胞浆内单精子显微注射(ICSI)的受精、胚胎发育、妊娠率的影响。方法:回顾性分析637例IVF-ET及ICSI患者的临床及实验室资料,并将其分为4组,A组:IVF-ET伴AsAb阳性,36例;B组:ICSI伴AsAb阳性,25例;C组:IVF-ET,AsAb阴性,413例;D组:ICSI,AsAb阴性,163例,分析各组受精率、优质胚胎率及妊娠率的差异。结果:A组受精率显著低于其他各组;A组优质胚胎率及妊娠率显著低于C组和D组;B组优质胚胎率及妊娠率与A组无显著性差异。结论:血清抗精子抗体的存在不但影响精子和卵子的结合,同样也影响胚胎的发育及种植,卵胞浆内单精子显微注射可提高受精率,但对提高胚胎质量及妊娠率无意义。Objective： To investigate the effect of anti - sperm antibody on in vitro fertilization - embryo transfer and intracytoplasmic sperm injection. Methods： This study retrospectively analyzed the clinical and laboratory data of 637 cases of IVF - ET and ICSI, all the cases were divided into 4 groups, group A ： 36 cases with AsAb received IVF - ET ; group B ： 25 cases with AsAb received ICSI ; group C ： 413 cases without AsAb received IVF -ET; group D： 163 cases without AsAb received ICSI. Results： Insemination rate of group A was decreased than other three groups, high quality embryo rate and clinical gestational rate of group A were decreased than group C and group D. Insemination rate of group B were increased than group A but high quality embryo rate and clinical gestational rate had no significant difference than group A. Conclusion： AsAb not only influence the combination of sperm and ovum, but also influence development and implantation of embryo; ICSI helped to insemination.

关 键 词：抗精子抗体 体外受精-胚胎移植 卵胞浆内单精子显微注射 受精率 妊娠率 

分 类 号：R715[医药卫生—妇产科学]