急性冠脉综合征患者HS-CRP和MMP-9变化对临床护理的意义  

Implication of Changes of Serum C-Reaction Protein and Matrix Metalloproteinase-9 in Patients with Acute Coronary Syndrome in Nursing

作　　者：高玉玲[1] 贾利新[1] 石维[1] 

机构地区：[1]解放军总医院老年心血管病研究所,北京市100853

出　　处：《中国康复理论与实践》2006年第6期480-481,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清高敏C-反应蛋白(HS-CRP)和基质金属蛋白酶-9(MMP-9)水平的变化及其在临床护理中的意义。方法检测103例ACS患者,其中包括不稳定性心绞痛(UA)56例,急性心肌梗死(AMI)47例,以及对照组(冠脉造影阴性)40例的血清HS-CRP和MMP-9含量,比较组间差异。结果UA组、AMI组和对照组的血清HS-CRP浓度分别为(3.87±0.76)g/L、(4.12±0.67)g/L和(1.67±0.38)g/L,MMP-9浓度分别为(113.25±7.76)ng/ml、(193.09±25.87)ng/ml和(42.05±3.81)ng/ml,ACS患者的血清HS-CRP和MMP-9浓度均明显高于对照组(P<0.01)。结论ACS患者的血清HS-CRP和MMP-9变化明显,可作为标志物用于指导临床护理工作。Objective To explore the changes of serum high sensitive C-reaction protein （HS-CRP） and matrix metalloproteinase- 9 （MMP-9） in patients with acute coronary syndrome （ACS） and their effects in nursing. Methods 103 ACS patients, including 56 cases of unstable angina （UA）） and 47 cases of acute myocardial infarction （AMI）, and other 40 persons （no abnormal results in coronary artery angiography, selected as control group） were examined for serum levels of HS-CRP and MMP-9. The difference among the groups was analyzed. Results The HS-CRP levels of UA group, AMI group and control group were （3.87±0.76）g/L, （4.12±0.67）g/L and （1.67±0.38）g/L respectively; MMP-9 were （113.25±7.76）ng/ml, （193.09±25.87）ng/ml and （42.05±3.81）ng/ml respectively. The concentrations of HS-CRP and MMP-9 of ACS patients were significatly higher than those of the control group （ P〈0.01）. Conclusion The changes of HS-CRP and MMP-9 concentrations of ACS patients are remarkable, and may be as the markers to instruct nursing works.

关 键 词：急性冠脉综合征 血清 高敏C-反应蛋白 基质金属蛋白酶-9 护理 

分 类 号：R543.3[医药卫生—心血管疾病]