表皮松解坏死型游走性红斑  

Necrolytic migratory erythema

作　　者：Kovcs R.K. Korom I. Dobozy A. 李政霄 

机构地区：[1]Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Hungary Kornyi fasor 6, H-6720 Szeged, Hungary Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第6期8-8,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Necrolytic migratory erythema is considered to be a paraneoplastic dermatosis. The classical symptoms are associated with α-cell pancreatic islet cell tumor or ‘glucagonoma’. Generally, extracutaneous hallmarks of this disease include weight loss, diabetes, anaemia and diarrhoea. Observation: We report a case of a 39-year-old woman with a 3-year history of recalcitrant psoriasiform eruption, who had no other associated symptoms on routine examination. Histologic examinations suggested necrolytic migratory erythema. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After distal resection of the pancreas her skin symptoms resolved in a few days time. Histology was consistent with glucagonoma. She is clinically well and symptomless and no signs of metastasis after 4 years. Conclusions: It is infrequent to have only necrolytic migratory erythema, hyperglucagonaemia and islet-cell tumor but no other extracutaneous symptoms in glucagonoma syndrome. To our knowledge, ours is the second such case reported in the literature. Skin symptoms are important, often they are the clue to the diagnosis of glucagonoma syndrome.Background： Necrolytic migratory erythema is considered to be a paraneoplastic dermatosis. The classical symptoms are associated with or-cell pancreatic islet cell tumor or ＇glucagonoma＇ Generally, extracutaneous hallmarks of this disease include weight loss, diabetes, anaemia and diarrhoea. Observation： We report a case of a 39-year-old woman with a 3-year history of recalcitrant psoriasiform eruption, who had no other associated symptoms on routine examination. Histologic examinations suggested necrolytic migratory erythema. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After distal resection of the pancreas her skin symptoms resolved in a few days time. Histology was consistent with glucagonoma. She is clinically well and symptomless and no signs of metastasis after 4 years. Conclusions： It is infrequent to have only necrolytic migratory erythema, h yperglucagonaemia and islet-cell tumor but no other extracutaneous symptoms in glucagonoma syndrome. To our knowledge, ours is the second such case reported in the literature. Skin symptoms are important, often they are the clue to the diagnosis of glucagonoma syndrome.

关 键 词：表皮松解坏死型 游走性红斑 胰高血糖素瘤综合征 组织病理检查 胰岛细胞瘤 副肿瘤性 女性患者 银屑病样皮损 典型症状 切除术后 

分 类 号：R758.25[医药卫生—皮肤病学与性病学] R758.61[医药卫生—临床医学]