口腔增殖型天疱疮  

Pemphigus vegetans of the oral cavity

作　　者：Markopoulos A.K. Antoniades D.Z. Zaraboukas T. 张路坤 

机构地区：[1]Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第6期58-58,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions (Neumann) or pustules (Hallopeau). Both subtypes subsequently develop into hyperpigmented vegetative plaques with pustules and hypertrophic granulation tissue at the periphery. Methods: We report three cases of pemphigus vegetans with oral manifestations exclusively. Two patients were male aged 30 and 45 years old, respectively,while one was a 51-year old female. Conclusions: Oral lesions in all cases consisted of erosions and whitish, vegetating plaques. The histopathological characteristics were in all cases identical. The spinous cell layer was characterized by intense acanthosis and by the presence of vesicles between the spinous and basal cell layers. Inside the vesicles exudative elements were observed consisting mainly of eosinophils. In the upper lamina propria severe inflammatory reaction was observed. Streptavidin-biotin immunoperoxidase technique showed in all cases intercellular epithelial deposition of IgG and C3.Background： Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions （Neumann） or pustules （Hallopeau）. Both subtypes subsequently develop into hyperpigmented vegetative plaques with pustules and hypertrophic granulation tissue at the periphery Methods： We report three cases of pemphigus vegetans with oral manifestations exclusively. Two patients were male aged 30 and 45 years old, respectively, while one was a 51-year old female. Conclusions： Oral lesions in all cases consisted of erosions and whitish, vegetating plaques. The histopathological characteristics were in all cases identical. The spinous cell layer was characterized by intense acanthosis and by the presence of vesicles between the spinous and basal cell layers. Inside the vesicles exudative elements were observed consisting mainly of eosinophils. In the upper lamina propria severe inflammatory reaction was observed. Streptavidin-biotin immunoperoxidase technique showed in all cases intercellular epithelial deposition of IgG and C3.

关 键 词：增殖型天疱疮 口腔损害 组织病理学特征 寻常型天疱疮 肉芽组织增生 水疱形成 过氧化物酶法 色素沉着性 嗜酸粒细胞 黏膜固有层 

分 类 号：R758.66[医药卫生—皮肤病学与性病学] R512.91[医药卫生—临床医学]