超声心动图评价抗心肌肌球蛋白抗体对急性心肌梗死病人左室重构及心功能的影响  

Effect of Anti-cardiac Myosin Antibody on Left Ventricular Remodeling and Function in AMI Patients by Echo-evaluation Infarction

作　　者：庞红[1] 吕清[2] 廖玉华[2] 汪朝晖[2] 

机构地区：[1]广东医学院附属南山医院 [2]华中科技大学同济医学院心血管病研究所/华中科技大学同济医学院附属协和医院

出　　处：《中西医结合心脑血管病杂志》2006年第1期13-15,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨抗心肌肌球蛋白抗体(AMA)与急性心肌梗死(AMI)病人左室重构及心功能的关系。方法选择AMI病人42例,其中10例AMA阳性及32例AMA阴性的病人,分别于发病7d和6个月后进行超声心动图检查,比较两组心功能参数的变化。结果6个月后观察左室短长轴比值(D/L)、左室质量(LVM);左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、每搏量(SV)、心排血量(CO)、左室射血分数(LVEF)、左室内径缩短率(FS)以及舒张早期心室充盈速度最大值E峰、舒张晚期心室充盈速度最大值A峰、E/A比值、E峰流速时间积分(E-VTI)、A峰流速时间积分(A-VTI)、E-VTI/A-VTI等指标,AMA阴性组均有显著改善(P<0.05),而阳性组无明显改变。结论AMA可能参与心肌损伤和心室重构,影响AMI病人的心功能和预后。Objective To investigate the relationship between anti - cardiac myosin antibody （AMA） and the left ventricular remodeling and function in patients （pts） with acute myocardial infarction. Methods The study included 42 pts with acute myocardial infarction. There were 10 pts in AMA positive group and 32 pts in AMA negative group. Left ventricular structure and cardiac function were examined by echocardiography at theend of the first week after infarction and at 6 month follow up. The parameters of left ventricular structure and function were compared between the two group. Results At six month follow up, the ventricular remodeling （D/L, LVM）, the ventricular systolic function （LVEDV, LVESV, EF, FS, CO, SV） and the ventricular diastolic function（E, A, E/A,E - VTI,A- VTI ,E - VTI/A- VTI） improved significantly（P 〈 0.05）in AMA negative group, but there were no significant changes in AMA positive group（P 〈 0.05）. Conclusion AMA might take part in myocardial injury and left ventricular remodeling after AMI, and there were some harmful effects to left ventricular function and the prognosis of AMI.

关 键 词：超声心动图 抗心肌肌球蛋白抗体 心肌梗死 急性 

分 类 号：R542.22[医药卫生—心血管疾病]