盐酸吡格列酮对2型糖尿病血管内皮功能的影响  

Effect of piogliazone hydrochloride on vascular endothelial function in type 2 diabetic patients

作　　者：赖晓阳[1] 沈云峰[1] 雷水红[1] 余戎[1] 刘泽林[1] 张美英[1] 邹芳[1] 

机构地区：[1]南昌大学第二附属医院内分泌科,南昌330006

出　　处：《江西医药》2006年第7期444-446,共3页Jiangxi Medical Journal

摘　　要：目的探讨盐酸吡格列酮干预治疗2型糖尿病(T2DM)血管内皮功能的影响。方法选择45例T2DM与40例正常人(NC),分别测各组血浆内皮素(ET)、超敏C反应蛋白(HsCRP)、尿白蛋白肌酐比(ACR)以及其他有关项目。并对45例T2DM加用盐酸吡格列酮干预治疗12周。结果与NC相比,T2DM组ET、HsCRP、ACR均显著升高(P<0.01)。T2DM组治疗后ET、HsCRP、ACR明显下降,胰岛素敏感性增加(P<0.05￣0.01)。结论盐酸吡格列酮对T2DM血管内皮功能具有保护作用。Objective To investigate the protective effects of piogliazone hydrochloride on vascular endothelial function in type 2 diabetic patients. Methods Forty five type 2 diabetic patients and forty normal control subjects（NC） were involved in this study.Plasma endothelian（ET）, High sensitivity C reactive protein（HsCRP）, Urinary albumin - to - creatintine ratio（ACR） and other items were measured in the each of the eligible subjects.Forty five type 2 diabetic patients were given the piogliazone hydrochloride for twelve weeks. Results Compared with NC,increased ET, HsCRP and ACR concentration at baseline in type 2 diabetic patients（P〈0.01）. After twelve weeks treatment with piogliazone hydrochloride,their ACR decreased from （83±12）mg/g to （36±15）mg/g （P〈0.01）.The levels of ET and HsCRP were significant decreased [ET：（92.7±8.5）pg/mL vs （64.3±8.0）pg/mL, P〈0.01;HsCRP：（6.9±1.9）mg/L vs （4.7±2.0）mg/L, P〈0.05]; meanwhile,HOMA-IR was decreased from （4.9±1.0） to （3.6±1.2） （P〈0.05）. Conclusion Piogliazone hydrochloride can improve endothelial dysfunction in type 2 diabetic patients,have protective effects on vascular endothelium.

关 键 词：盐酸吡格列酮 2型糖尿病 血管内皮功能 

分 类 号：R977.15[医药卫生—药品] R587.1[医药卫生—药学]