谷氨酸镁在兔体内的药物动力学研究  

PHARMACOKINETICS OF MAGNESIUM GLUTAMATE IN RABBITS

作　　者：邵仁英[1] 汤韧[1] 王志朝[1] 吴文姗 王飞 

机构地区：[1]广州军区武汉总医院

出　　处：《中国医药工业杂志》1996年第9期395-396,共2页Chinese Journal of Pharmaceuticals

摘　　要：家兔静脉推注谷氨酸镁溶液剂（８８ｍｇ／ｋｇ）后，采用镁试剂比色法在５４０ｎｍ波长处测定其血清镁离子浓度，并将其与硫酸镁的药物动力学参数进行比较。使用ＰＫＢＰ－Ｎ１药物动力学程序包进行拟合，表明镁的代谢过程表现为二房室模型。其主要药动学参数为：Ｔ＿（１／２α）＝０．１５ｈ，Ｔ＿（１／２β）＝９．４８ｈ，α＝４．４９ｈ￣（－１），β＝０．０７ｈ￣（－１），ｋ＿（１２）＝２．１６ｈ￣（－１），ｋ＿（２１）＝２．２３ｈ￣（－１），ｋ＿（１０）＝０．１５ｈ￣（－１）。Serum magnesium level of rabbits was colorimetrically determined after intravenous injection of magnesium glutamate solution using magnesium reagent at the wavelenghth of 540nm. PKBP-N1 program package was utilized for estimation of Pharmacokinetic Parameters. Two compartment model was adopted in computer simulation. The pharmacokinetic parameters were as follow: α=4.49h￣(-1),β=0.07h￣(-1), T_(1/2α)=0. 15h,T_(1/2β)=9.48h, k_(12)=2.16h￣(-1), k_(21)=2. 23h￣(-1),k_(10)=0.15h￣(-1). The parameters were compared with those of magnesium sulfate.

关 键 词：谷氨酸镁 镁试剂 比色法 药物动力学 

分 类 号：R977.5[医药卫生—药品]