我国不同肝炎患者及献血员中SENV-D/H感染流行病学调查  

Prevalence of SEN Virus D and H Subtype Infection in Different Type of Hepatitis and Blood Donors

作　　者：穆士杰[1] 陈蕤[1] 李丁[2] 张献清[1] 

机构地区：[1]第四军医大学西京医院输血科,陕西西安710032 [2]第四军医大学全军基因诊断研究所,陕西西安710032

出　　处：《现代检验医学杂志》2006年第4期10-12,共3页Journal of Modern Laboratory Medicine

摘　　要：目的了解SEN病毒(SENV)D亚型和H亚型在我国不同肝炎患者和献血员中的感染情况。方法采用巢式聚合酶链反应对收集的270例健康献血者和484例各型肝炎患者(包括甲肝、乙肝、丙肝和非甲非戊型肝炎患者)进行SENV-D亚型和H亚型DNA检测。结果无偿献血者中SENV-D的感染率为25.9%,SENV-H为24.4%;急性甲肝患者中SENV-D的感染率为14.5%,SENV-H为32.7%;慢性乙肝患者中SENV-D的感染率为46%,SENV-H为45.2%;在丙肝患者中SENV-D和SENV-H感染率均为65%;在非甲-非戊型肝炎患者中SENV-D的感染率为51.2%,SENV-H为43.9%。结论SENV可能与HCV和HBV具有一样的传播方式,但并不是肝病发生的原因。Objective To investigate the prevalence of SENV-D/H in different type of hepatitis and blood donors. Methods The SENVD/H subtype DNA were detected in 754 different hepatitis and blood donors in china by nested PCR. Results The SENV-D/H positive rate in healthy donors were 25.9%and 24. 4% ,from which 14. 5%and 32. 7%in acute hepatitis A patients , 46 %and 45. 2% in chronic hepatitis B patients, 65% in hepatitis C patients,51.2%and 43.9% in hepatitis non A-E patients. Conclusion SENV probably has the same ways of spreading as HCV and HBV,but is not responsible for hepatitis.

关 键 词：SENV—D亚型 SENV—H亚型 流行病学 巢式聚合酶链反应 

分 类 号：R512.6[医药卫生—内科学]