健康成年人血浆肌酐生物参考区间调查  

Investigating of Reference Intervals of Plasma Creatinine

作　　者：卢燕君[1] 石汉振[1] 林莲英[1] 王美兰[1] 冯妙芙[1] 黄宪章[1] 庄俊华[1] 

机构地区：[1]广东省中医院检验科,广东广州510120

出　　处：《现代检验医学杂志》2006年第4期35-36,共2页Journal of Modern Laboratory Medicine

基　　金：国家高新技术研究发展计划(863计划)课题资助(2004AA2Z3762)

摘　　要：目的 通过测定广州市健康成年人群的肝素锂抗凝血浆肌酐值，建立该实验室血浆肌酐的生物参考区间。方法 采用碱性苦味酸速率法对959例健康成年人（年龄〉18y，其中男442例，女517例）进行血浆肌酐的测定，并按性别和年龄组分别比较。结果 血浆肌酐结果呈对数正态分布，成年人肌酐值男女间差异有统计学意义（P〈0．01），成年健康男性年龄组肌酐值差异无显著性（P〉0．05），其95％可信限的生物参考区间为57．3～111．3μmol／L；女性61y以上的年龄组与其他成年女性年龄组之间肌酐值差异有显著性（P〈0．05），年龄18～60y健康女性95％可信限的参考区间为43．8～83μmol／L，年龄61y以上健康女性95％可信限的参考区间为45～97μmol／L。结论 生物参考区间对疾病的预防、诊断、疗效及预后都有重要的指导意义，应依据标本类型、检测方法和检测人群制定适合各实验室的生物参考区间。Objective To set up reference intervals of plasma creatinine in clinical laboratory. Methods Plasma creatinine was measured in 959 health adults whose age were above 18（442 males and 517 females） by using Jaffe kinetic assay in Roche Modular 020 analyzer, the data were analyzed. Results Plasma creatinine levels distribution was logarithm normal distribution, There was significant difference between male and female adult groups（P〈0. 01）. There was no significant difference among male adult groups, reference intervals of plasma creatinine of health male adults was 57.3 μmol/L to 111.3μmol/L. There was significant difference between female whose age were more than 61 years old groups and adult female whose age were less than 61 years old groups （P〈0. 05）. There was no significant difference among other female adult groups. Reference intervals of plasma creatinine of health female adults was 43. 8 μmol/L to 83μmol/L whose age were among 18～60 years old and was 45 μmol/L to 97 μmol/L whose age were more than 61 years old. Conclusion Reference intervals are important for early prevention, diagnosis, therapeutic effect and prognosis of disease. Each clinical laboratory should establish itself different reference intervals.

关 键 词：生物参考区间 血浆肌酐 

分 类 号：R446.112[医药卫生—诊断学]