2型糖尿病患者不对称二甲精氨酸浓度变化及临床意义  

Changes and Clinical Significance of Asymmetric Dimethylarginine in Non-insulin Dependent Diabetes Mellitus

作　　者：张润香[1] 李菊香[1] 熊建球[1] 

机构地区：[1]南昌大学第二附属医院检验科,江西南昌330006

出　　处：《现代检验医学杂志》2006年第4期61-62,共2页Journal of Modern Laboratory Medicine

基　　金：江西省自然科学基金资助项目(9940029)

摘　　要：目的观察2型糖尿病(non-insu lin dependen t d iabetes m e llitus,N IDDM)患者血浆中不对称二甲精氨酸(asym-m etric d im ethy larg in ine,ADM A)浓度变化以及对一氧化氮(n itric ox ide,NO)和内皮素(endothe lin,ET)的影响,并探讨其临床意义。方法采用高效液相色谱法(h ighperforance liqu id chrom atography,HPLC)、硝酸盐还原酶比色法及放射免疫法,分别对98例N IDDM患者(其中并发血管病变者54例)血浆中ADM A、NO、ET浓度进行测定,并与30例健康人进行对比分析。结果N IDDM患者与健康人相比,患者血浆中ADM A、ET浓度明显增高,NO浓度明显降低,差异均有显著性意义(P<0.05),并发血管病变者较无并发症者这种变化更显著(P<0.01)。结论ADM A是内皮功能障碍的一个新的危险因子。血浆ADM A浓度变化在N IDDM血管并发症的发生发展过程中起重要作用。Objective To investigate the changes and clinical significance of plasma asymmetric dimethylarginine（ADMA）, nitric oxide（NO） and endothelin（ET） in non-insulin dependent diabetes mellitus （NIDDM）. Methods The levels of plasma ADMA,NO and ET were determined in 98 patients with NIDDM（of them,54 were complicated with vascular disease） and 30 normal controls by highperforance liquid chromatography （HPLC）,nitrate redactase colorinietry and RIA respectively. Results Compared with normal controls,the levels of plasma ADMA and ET in NIDDM patients were higher （P〈 0. 05） and NO was lower（P〈0. 05）. The alterations were notable especially in the patients complicated with vascular disease （P〈0. 01）. Conclusion ADMA could be a new risk factor and the change of ADMA level may play an important role in NIDDM complicated with vascular disease.

关 键 词：糖尿病 不对称二甲精氨酸 对比研究 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]