活血化瘀中药对清解通下中药增效作用的实验研究V——对粘连组织中MMP-1和TIMP-1影响的实验研究  

Experimental Study on Intensive Effects of Herbs of Huoxue Huayu(活血化瘀) on Qingjie Tongxia(清解通下) Herbs V——Influence on MMP-1 and TIMP-1 of Peritoneal Adhesions in Rats

作　　者：尚晓滨[1] 吴咸中[2] 李东华[2] 郭世铎[2] 

机构地区：[1]天津医科大学,博士研究生天津300052 [2]天津市中西医结合急腹症研究所

出　　处：《中国中西医结合外科杂志》2006年第4期385-388,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市科委重点支持课题(023111511)

摘　　要：目的通过大鼠腹膜粘连动物模型,观察活血清下汤(由活血化瘀中药复方丹参+清解通下中药加味小承气汤两方组合而成)的多靶点治疗作用,探讨活血化瘀中药对清解通下中药的增效作用。方法采用盲肠结扎加穿孔法制作大鼠腹膜粘连动物模型,对粘连组织的MMP-1和TIMP-1进行检测。结果应用活血清下汤可以显著降低TIMP-1的表达水平,提高MMP-1的表达水平,较单用加味小承气汤或复方丹参方效果显著。结论活血清下汤对防治腹膜粘连形成,比单用加味小承气汤或复方丹参效果更为显著。提示活血化瘀中药对清解通下中药存在增效作用。Objective To observe multi-effects of Huoxue Qingxia（活血清下） decoction（HXQX） on peritoneal adhesions in rats in order to verify that Huoxue Huayu（活血化瘀） herbs can enhance the effects of Qingjie Tongxia（清解通下） herbs Methods Rat models of peritoneal adhesions were established with cecal ligation plus puncture （CLP）, and adhesive tissues were obtained for detection of MMP-1 and TIMP-1. Results Treated with HXQX decoction, TIMP-1 was decreased, but MMP-1 was increased. Conclusion Peritoneal adhesions can be prevented and treated by Huoxue Qingxia decoction, and Huoxue Huayu herbs can enhance the effects of Qingjie Tongxia herbs when peritoneal adhesions occur.

关 键 词：活血化瘀 清解通下 粘连/预防和治疗 基质金属蛋白酶 基质金属蛋白酶抑制物 

分 类 号：R656.1[医药卫生—急诊医学]