Synthesis of 2-(Benzodioxol-2-yl)acetic Acids as PPARδAgonists  

作　　者：Jian Lei KANG Zhi Bing ZHENG Dan QIN Li Li WANG Song LI 

机构地区：[1]School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016 [2]Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

出　　处：《Chinese Chemical Letters》2006年第8期1013-1016,共4页中国化学快报（英文版）

基　　金：supported by the National High Technology Research and Development Program of China(863 project:2003AA235010);the National Natural Science Foundation of China(No.30472092).

摘　　要：A new series of compounds, 2-（benzodioxol-2-yl）acetic acids, have been synthesized. Their structures were confirmed by MS and 1H-NMR. The preliminary pharmacological screening showed that these compounds exhibited potent human PPARδ agonist activities.A new series of compounds, 2-（benzodioxol-2-yl）acetic acids, have been synthesized. Their structures were confirmed by MS and 1H-NMR. The preliminary pharmacological screening showed that these compounds exhibited potent human PPARδ agonist activities.

关 键 词：PPARδ agonists 2-（benzodioxol-2-yl）acetic acids synthesis. 

分 类 号：O625.5[理学—有机化学]