Synthesis of Novel Bisoxazoline Ligands for the Enantioselective Diels-Alder Reaction  

作　　者：Qing Hua BIAN Jun LIU Ming Ming YIN Min WANG 

机构地区：[1]College of Science, China Agricultural University, Beijing 100094

出　　处：《Chinese Chemical Letters》2006年第8期1033-1036,共4页中国化学快报（英文版）

基　　金：Finacial support by the National Natural Science Foundation of China(No.2047211);the Science Foundation of China Agricultural University(No.2005058)is gratefully acknowledged.

摘　　要：Four novel bisoxazoline ligands 8a-d were synthesized from （S）-amino alcohols and could be formed effective catalysts （up to 77% ee for endo isomer） with Cu（OTf）2 for enantioselective Diels-Alder addition. The facility of the reaction was dependent on the nature of the substituent R in the bisoxazoline ligand.Four novel bisoxazoline ligands 8a-d were synthesized from （S）-amino alcohols and could be formed effective catalysts （up to 77% ee for endo isomer） with Cu（OTf）2 for enantioselective Diels-Alder addition. The facility of the reaction was dependent on the nature of the substituent R in the bisoxazoline ligand.

关 键 词：Asymmetry catalytic BISOXAZOLINE Diels-Alder reaction ligand. 

分 类 号：O626.4[理学—有机化学]