通腑泻热方治疗腹部外科疾病并发全身炎症反应综合征的临床观察  

Clinical Observation on Effect of Tongfu Xiere Recipe in Treating Surgical Abdominal Diseases Accompanied with Systemic Inflammatory Response Syndrome

作　　者：谢晓华[1] 程宇星[1] 周文高[1] 

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《中国中西医结合杂志》2006年第7期594-596,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：广东省中医药管理局科研基金资助项目(No.099514)

摘　　要：目的观察中药通腑泻热方治疗腹部外科疾病并发全身炎症反应综合征的效果。方法在常规腹部外科手术及术后处理、抗生素应用治疗的基础上,给予中药通腑泻热方治疗本病46例,与常规治疗的43例作对照观察。结果与对照组比较,治疗组并发症发生率明显降低(P<0·01),其中多器官功能障碍综合征(MODS)发生率及病死率呈下降趋势;治疗后血浆内毒素、TNF-α、IL-6、IL-8均显著降低(P<0·01),IL-2明显升高(P<0·01)。结论通腑泻热方能降低腹部外科疾病并发全身炎症反应综合征患者血中内毒素及促炎细胞因子水平,能提高与机体免疫功能直接相关的细胞因子,具有免疫调理和遏制全身炎症反应作用,进而可防治MODS,降低病死率。Objective To observe the effect of Tongfu Xiere Recipe （TXR） on surgical abdominal diseases accompanied with systemic inflammatory response syndrome （SIRS）. Methods Forty-six patients in the postoperational stage were treated by basic therapy, including conventional treatment and antibiotics applying, and combined use of TXR, and compared with the 43 patients treated by basic therapy alone as the control group. Results Compared with the control group, the incidence of complications in the treatment group was significantly lower （P 〈 0.01）, The incidence of multiple organ dysfunction syndrome （MODS） and the mortality in the treatment group showed an decreasing tendency. Moreover, levels of plasma endotoxin, TNF-a, IL-6 and I L-8 in the treatment group after treatment decreased significantly, while I L-2 level increased （P 〈 0.01）, and showed a significant difference （P 〈 0.01） as compared with those in the control group. Conclusion The combined therapy can decrease the levels of blood endotoxin and inflammation promoting cytokine and increase the level of cytokine that directly related with immune function to regulate immunity and inhibit the inflammatory reaction, and furthermore, to prevent MODS and decrease the mortality of patients with surgical abdominal diseases accompanied SIRS.

关 键 词：通腑泻热方 腹部外科疾病 全身炎症反应综合征 

分 类 号：R26[医药卫生—中医外科学]