左卡尼汀对冠心病高胆固醇血症的疗效观察  

Effects of L-Carnitine on hypercholesterolemia in patients with coronary heart disease

作　　者：成静[1] 盛净[1] 杜勤[1] 蔡文玮[1] 

机构地区：[1]上海交通大学附属第九人民医院老年科,上海200011

出　　处：《心脏杂志》2006年第4期430-431,435,共3页Chinese Heart Journal

摘　　要：目的 观察左卡尼汀在冠心病高胆固醇血症患者中的临床疗效及其安全性。方法 选择冠心病伴高胆固醇的患者40例，予左卡尼汀3．0g／d，连续15d静脉滴注，以后改用左卡尼汀1：3服液1．0g，3次／d，连续15d。治疗前后比较每周心绞痛发作次数以及硝酸甘油片用量，心电图、超声心动图、血脂、肝肾功能生化指标变化。结果 左卡尼汀治疗2～4周后患者心绞痛发生次数及硝酸甘油片用量显著减少，ST段缺血型下移之和∑ST减小，心脏指数和左室射血分数显著改善；左卡尼汀治疗后2周总胆固醇和甘油三脂降低，高密度脂蛋白胆固醇升高。结论 左卡尼汀可以缓解冠心病患者的临床症状，减轻心肌缺血，改善心功能，并且可以调节血脂水平，不良反应少。AIM To observe the therapeutic effects of L-Carnitine on hypercholesterolemia in patients with coronary heart disease. METHODS Forty patients with hypercholesterolemia diagnosed as coronary heart disease （CHD） were treated by L-Carnitine for 30 days. Angina pectoris attack frequency, weekly nitroglycerin consumption, electrocardiogram, uhrasonography, serium lipids and hepatic -renal function were measured before and after the therapy. RESULTS ①After L-Carnitine treatment, angina pectoris attack frequency and weekly nitroglycerin consumption decreased obviously and ∑ST depression improved. The cardiac index （CI） and left heart ejecting function （EF） increased after the 2 -4 weeks treatment. ③The total serum cholesterol and triglyceride decreased and HDL-Cholesterol level increased after L-Camitine treatment. CONCLUSION L-Carnitine has obvious anti - ischemic effect on CHD pa- tients and a good protective effect on myocardium. It can also regulate the level of serum lipids with few side effects.

关 键 词：冠状动脉疾病 左卡尼汀 高脂血症 

分 类 号：R541.6[医药卫生—心血管疾病]