不稳定型心绞痛患者斑块易损性的血管内超声评价  

Evaluation of Vulnerable Plaques with Intravascular Ultrasound in Patients with Unstable Angina

作　　者：刘运芳[1] 赵玉霞[1] 张澄[1] 于会明[2] 钟宁[2] 黄涛[2] 

机构地区：[1]山东大学齐鲁医院,济南市250012 [2]山东大学医学院

出　　处：《中国超声医学杂志》2006年第8期601-603,共3页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金资助项目(30472262)

摘　　要：目的应用血管内超声（IVUS）技术评价不稳定型心绞痛患者易损斑块的影像学特征。方法对11例稳定型心绞痛，17例不稳定型心绞痛患者和11例正常对照者进行血脂、体表血管超声和血管内超声检查。结果两组心绞痛患者的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）和内膜一中层厚度（IMT）显著高于正常对照组（P〈0.05）。IVUS示不稳定型心绞痛组病变处血管外弹力膜面积（EEMA）、斑块面积（PA）、管腔面积狭窄百分率（LAS％）、偏心指数（EI）及重构指数（RI）均显著高于稳定型心绞痛组（P〈O，01～O，05），Logistic回归分析显示IMT、PA和RI具有显著性差异。结论IMT、PA和RI是预测冠状动脉AS斑块易损性的重要指标，IVUS在易损斑块的早期识别中具有独特的优势。Objective To discuss the imaging features of vulnerable plaques with intravascular ultrasound （IVUS） in patients with unstable angina, Methods Both sides of carotid arteries were examined with high frequency ultrasound and coronary artery were detected with IVUS in 11 patients with stable angina, 17 patients with unstable angina ,and 11 control patients without coronary artery disease, Results TC,LDL-C and IMT in patients with angina were significantly higher than those in the control group （P〈0. 05） , Compared to patients with stable angina, extravascular elastic membrance area （EEMA）, plaque area （PA）, lumen area stenosing, （LAS%）, eccentric index （EI） and remodeling index （RI） in patients with unstable angina were significantly higher （P〈0. 01- 0. 05） . Results of Logistic regression analysis showed that risk factors were IMT, PA and RI. Conclusions IMT, PA and RI are important predictors of vulnerable plaques. IVUS has unique priority as a reliable method for the early discovery of vulnerable plaques.

关 键 词：动脉粥样硬化 易损斑块 血管内超声 

分 类 号：R541.4[医药卫生—心血管疾病] R543.5[医药卫生—内科学]