盐酸吡格列酮对肌肉组织胰岛素抵抗发生的影响  

Effects of pioglitazone on the insulin resistance in the muscle tissue

作　　者：柳红芳[1] 陆菊明[1] 母义明[1] 陆祖谦[1] 肖君[1] 詹晓蓉[1] 潘长玉[1] 

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《军医进修学院学报》2006年第4期251-253,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金资助(30270628)

摘　　要：目的:探讨盐酸吡格列酮对饱和脂肪酸诱导的大鼠肌肉组织胰岛素抵抗发生的影响。方法:45只雄性W istar大鼠分为3组。对照组喂饲普通块料,高脂组喂饱和脂肪酸提供59%KJ的高脂饲料,盐酸吡格列酮组在喂饲高脂饲料的同时,灌胃给盐酸吡格列酮10 mg.kg-1.d-1。各组喂饲11周后测定各项指标。结果:与对照组比较,高脂组大鼠体内脂肪相对含量、空腹血糖、血清胰岛素、甘油三酯、胆固醇、胰岛素抵抗指数、肌肉中甘油三酯含量均显著升高;而肌肉组织中胆固醇含量无显著改变,高脂组肌肉胰岛素受体含量、肌肉GLUT4蛋白的相对含量均明显下降。盐酸吡格列酮组体内脂肪相对含量、空腹血糖、甘油三酯、胆固醇、胰岛素和胰岛素抵抗指数、肌肉组织中甘油三酯含量均较高脂组明显降低。肌肉细胞膜胰岛素受体含量和GLUT4蛋白含量与高脂组无显著差异。结论:盐酸吡格列酮干预胰岛素抵抗的作用在肌肉组织主要表现在减轻组织中甘油三酯的沉积。Objective： To investigate the effects of pioglitazone on the insulin resistance in the muscle tissue. Methods：Forty-five male rats were divided into 3 groups including control, high fat-fed and pioglitazone group. The control rats were fed with common diet. The high fat-fed group were fed with high fat diet containing 59% saturated free fatty acids. The rats of pioglitazone group were fed with 10mg·kg^-1·d^-1 pioglitazone with high fat diet. These items were detected after each group was fed for 11 weeks. Results： （ 1 ） The relative content of visceral fat, fasting glucose, serum insulin, serum cholesterol and serum triglyceride, insulin resistance index, triglyceride in muscle were significantly higher in high fat-fed group than those in the control rats, but the cholesterol in muscle was not obviously changed. The relative content of liver and muscle insulin receptor and muscle GluT4 were decreased in high fat-fed group compared with these in the control. （2） In pioglitazone group, the relative content of visceral fat, fasting glucose, serum insulin, serum cholesterol and serum triglyeefide, insulin resistance index , triglyeeride in muscle were significantly decreased. The relative content of insulin receptor in muscle and GluT4 in muscle were not obviously changed. Conclusion： The decreased deposition of triglyeefide in the muscle tissue is the main effects of pioglita- zone on the insulin resistance in rats.

关 键 词：盐酸吡格列酮 胰岛素抗药性 肌肉骨骼系统 

分 类 号：R458.5[医药卫生—治疗学]