铜绿假单胞菌耐药性与五种抗假单胞菌抗生素使用量相关性研究  

Analysis of the correlation between the yearly quantity variations of clinical prescription of 5 drugs and the resistance of Pseudomonas aeruginosa

作　　者：罗燕萍[1] 沈定霞[1] 裴保香[2] 徐雅萍[1] 白立彦[1] 

机构地区：[1]解放军总医院微生物科,北京100853 [2]解放军总医院药材处,北京100853

出　　处：《军医进修学院学报》2006年第4期304-305,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：通过调查某三级甲等医院1994～2003年铜绿假单胞菌对五种抗生素的耐药性与这些药物的年用量，探讨用药量和耐药性之间的相关性。方法：纸片扩散法进行药敏试验并对1994～2003年5种抗生素的年用药频度（DDDs）与铜绿假单胞菌的耐药率进行相关性分析。结果：10年来铜绿假单胞菌对5种抗生素的耐药率逐年增长，而且耐药率增加均大于12．5％。亚胺培南和环丙沙星用量与铜绿假单胞菌对这两种药物耐药率的变化呈显著正相关，与该菌对哌拉西林的耐药率也有相关性。结论：亚胺培南和环丙沙星的年用量不仅与铜绿假单胞菌对这两种抗生素的耐药率其呈显著正相关，并且与哌拉西林的耐药率也呈正相关性。Objective ：To investigate the quantity of five kinds of antomicrobial agnets priscribed yearly from 1994 to 2003 and the resistance of Pseudomonas aerugonosa, and analyze the correlation between them. Methods： Susceptibility test to antimicrobial agnets was performed by disk diffusion method and analysed by WHONE 5.3 . The correlation between DDDS and the resistance were analyzed using statistics. Results：The percentage of resistance of Pseudomonsa aeruginosa to the five drugs increased with years. The increase of resistance was more than 12.5% for each .antimicrobial agent compared result from 1994 with that from 2003. The analysis revealed a significant positive correlation between the resistance and DDDS of imipenem and ciprofloxacin. The consumption of imipenem and ciprofloxacin is also related to the resisitance of Pseudomonsa aeruginosa to piperacillin. Condusions,The correlation between the use of imipenem and ciprofloxaciu and their resistance in Pseudomonsa aeruginosa strains, also revealed an association between imipenem and ciprofloxacin consumption and resistance to piperacillin.

关 键 词：铜绿假单胞菌 抗药性 抗生素类 

分 类 号：R446.5[医药卫生—诊断学]