药物代谢酶昼夜节律的变化观察与中医学“择时用药”原则探讨  

Studies on the Optimum Time for TCM Administration Based on the Diurnal Rhythmic Activities of Drug Metabolizing Enzymes

作　　者：李德淳[1] 朱理璎[1] 

机构地区：[1]天津中医学院,300193

出　　处：《中草药》1996年第8期479-481,共3页Chinese Traditional and Herbal Drugs

摘　　要：应用现代酶学实验方法观察了鼠肝微粒体药物代谢酶的3项指标随时间变化的情况，结果表明：细胞色素P450总量、NADPH细胞色素C还原酶和二甲基亚硝胶脱甲基酶3项指标均具昼夜节律性变化。这一结果对探讨中医学择时用药原则有一定意义。择时用药即选择药物最佳作用时间，从而达到临床效果的时间治疗学方法。　Diurnal rhythmic activities of three liver microsomal drug metabolizing enzymes, cytochrome P450,NADPH-cytochrome C reductase and N-nitrosodimethyl amine demethylase were selected and studies. All of them had a remarkable diurnal rhythm in rats.Their peak values were from 9:00 PM to 12:00 PM midnight,while the valley were at 6:00 dawn. Such rhythmicity correlated well with the metabolism of most TCM.Thus it was postulated that an optimum time for TCM administration could be selected based on this principle

关 键 词：药物代谢酶 昼夜节律 时间中医学 

分 类 号：R285.1[医药卫生—中药学] R226[医药卫生—中医学]