复方蛇制剂急性毒性及镇痛抗炎药效研究  

Acute Toxicity Analgesic and Antiinflammatory Effects of Snake Compound

作　　者：刘艳霞[1] 白凤菊[1] 娄建石[1] 康毅[1] 韩永晶[1] 吴红兵[2] 徐水林 方涌强 叶军妹 徐仲仙[2] 徐声林 方迪荣 

机构地区：[1]天津医科大学药理教研室,300070 [2]杭州市药物研究所

出　　处：《中草药》1996年第9期539-541,共3页Chinese Traditional and Herbal Drugs

摘　　要：实验观察了复方蛇制剂的急性毒性及其镇痛、抗炎作用。结果表明：口服复方蛇制剂，小鼠的最大耐受量为120g／kg，是病人临床常用剂量的1091倍，该制剂基本无毒。复方蛇制剂使醋酸所致小鼠扭体次数极显著减少，使电刺激小鼠痛阈值明显提高，其镇痛作用与剂量相关。复方蛇制剂使角叉菜引起大鼠足跖炎性肿胀显著减轻，使二甲苯所致小鼠右耳炎性肿胀显著减轻，结果表明：复方蛇制剂确有抗炎作用，且在一定范围内效应随剂量增加而增强。Snake compound (SC)consisted of the alcoholic extract of Zaocys dhumnades,Agkistrodon halys(Pallas)compounded with Chinese herbs: Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao, Angelica sinensis (Oliv) Diels, Rehmannia glutinosa Libosch, Paris pollyphylla Sm. var. yunancnsis, Epimedium brevicornum Maxim and Salvia miltiorrhiza Bge.. Acute toxicity test showed that the maximum tolerant oral dose for mice was 120mg/kg, 1091 times higher than the dose used in clinic for patients. Analgesic and anti-inflammatory studies showed that the times of writhe induced by abdominal administration of acetic acid were decreased significantly and the pain thre shold of electrical stimuli was increased markedly by SC in mice. The analgesic effects were dose-dependent. Inflammatory swelling in digiti pedis of rats induced by carrageenin and swelling of ear in mice were alleviated dramatically by SC.SC showed good effects in the treatment of winddampness syndrome and anthralgia syndrome in clinic.

关 键 词：复方蛇制剂 毒性 镇痛作用 

分 类 号：R285[医药卫生—中药学]