氧化应激与糖尿病神经病变  

Oxidative Stress and Diabetic Neuropathy

作　　者：张德刚[1] 赵瑛[1] 

机构地区：[1]第二军医大学附属长征医院神经内科,上海200003

出　　处：《医学综述》2006年第16期990-993,共4页Medical Recapitulate

基　　金：上海市科委重大攻关项目(04dz19503)

摘　　要：当细胞内的自由基产物超出其自身的抗氧化能力时,便会产生氧化应激。糖尿病时由于葡萄糖代谢异常,自由基产生过多,导致氧化应激。急性或慢性的高血糖均可促使周围神经组织内自由基的产生,促进糖尿病神经病变的发展。动物实验和临床研究中针对氧化应激进行的抗氧化治疗,均取得了一定的疗效,提示氧化应激在糖尿病神经病变中发挥重要作用。Oxidative stress occurs in a cellular system when the production of free radical moieties exceeds the antioxidant capacity of that system. Diabetes often has oxidative stress because of overloaded free radicals resulting from abnormal glucose metabolism. Both acute and chronic hyperglycemia can cause oxidative stress in the peripheral nervous system and promote the development of diabetic neuropathy. Examination of the data from Animal models of diabetes and clinical trials using antioxidants strongly suggested that oxidative stress play an important role in diabetic neuropathy.

关 键 词：糖尿病神经病交 氧化应澉 自由基 抗氧化剂 

分 类 号：R587.2[医药卫生—内分泌]