慢性肾衰竭患者微炎症状态与脂蛋白(a)及动脉粥样硬化的关系  

Relationship of Microinflammatory State and Lipoprotein(a) and Atherosclerosis in Patients with Chronic Renal Failure

作　　者：丁德良[1] 郑国俊[1] 李环波[1] 何立红[1] 陈光辉[1] 

机构地区：[1]广东省中山市小榄人民医院肾内科,528415

出　　处：《实用全科医学》2006年第5期531-532,共2页Applied Journal Of General Practice

摘　　要：目的探讨慢性肾衰竭患者微炎症状态与脂蛋白(a)[Lp(a)]及动脉粥样硬化的关系。方法检测60例慢性肾衰竭患者血清C反应蛋白(CRP)、Lp(a)并与健康对照组比较,同时对患者行颈动脉B超检测;分析其微炎症状态及其与脂蛋白(a)、颈动脉粥样硬化的关系。结果患者血清CRP和Lp(a)水平均高于对照组(P<0.01);患者血清CRP水平≥4 mg/L比<4 mg/L其平均颈总动脉内膜-中层厚度(IMT)、粥样斑块发生率明显升高(P<0.01)。血Lp(a)与CRP、平均IMT、粥样斑块发生率呈明显正相关(P<0.01)。结论慢性肾衰竭患者存在微炎症状态,这种微炎症状态可能通过某种途径导致Lp(a)代谢异常从而参与了慢性肾衰竭动脉粥样硬化并发症的发生与发展。Objective To research the relationship of the microinflammatory state, lipoprotein （a） and atherosclercsis in patients with chronic renal failure. Methods C reactive protein （CRP） and lipoprotein（a） [Lp（a） ] of 60 patients with chronic renal failure were detected and compared with control group, and carotid was examined by ultrasonic at the same time. The relationship of the microinflammatory state, lipoprotein （a） and atherosclerosis was analyzed. Results The patients＇ average carotid intimal media thickness （IMT） and level of CRP in serum were higher than that of controls, the IMT and incidence of atherosclerosis in patients whose CRP in serum was more than 4 mg/L was thicker or higher than those in patients whose CRP is less than 4 mg/L （ P〈0.01 ）. The relationship of Lp（a） and CRP, IMT and incidence of atherosclerosis was positive correlation （P〈0.01）. Conclusions Microinflammatory state can cause the metabolism abnormality of Lp（a） in patients with chronic renal failure, and it may be a probable cause in the occurrence and development of atherosclerosis.

关 键 词：慢性肾衰竭 微炎症状态 动脉粥样硬化 脂蛋白(a) 

分 类 号：R692.5[医药卫生—泌尿科学]