养肝利胆颗粒保肝利胆作用的实验研究  

Experimental Studies of "Yanggan Lidan Granule" in Improving Choleresis and Protecting Liver

作　　者：高建平[1] 金若敏[1] 朱培庭[2] 宁炼[3] 张海贵[1] 

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学附属龙华医院,上海200032 [3]上海市药品检验所,上海200233

出　　处：《上海中医药杂志》2006年第8期59-61,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委基金资助项目(01439304)

摘　　要：目的观察与养肝利胆颗粒功能主治相关的保肝和利胆作用。方法采用CCl4亚急性肝损伤小鼠模型和结石性胆囊炎大鼠模型,观察药物的保肝作用;采用大鼠胆总管引流的方法,观察该药的利胆作用。结果养肝利胆颗粒可明显降低CCl4模型小鼠血清ALT、AST活性和肝组织MDA含量,升高肝组织的SOD活性,能不同程度改善肝细胞的病理变化;可降低结石性胆囊炎模型大鼠成石率和血清AST、ALT活性,减轻肝脏的病理性变化;能增加麻醉大鼠的胆汁流量。结论养肝利胆颗粒具有保肝和利胆作用。Objective To investigate the functions of ＂Yanggan Lidan Granule＂ （YGLDG） in protecting liver and improving choleresis. Method The model of mouse liver injury induced by carbon tetrachloride （CC14） and the model of guinea pig calculous cholecystitis were used to observe the effects of YGLDG by oral administration. The bile volume was determinied by common bile duct drainage. Results YGLDG could significantly inhibit the increased serum ALT and AST activities, reduce liver MDA level, increase the activity of SOD in liver, evidently alleviate CC14-induced liver histopathological injures in model mice. It could reduce the rate of gallstone formation, obviously decrease the increased serum activity of ALT and AST, alleviate gallstone-induced liver histopathological injures in model guinea pigs. YGLDG could significantly promote the choleresis in anesthetic rats. Conclusion The results show that YGLDG has the effects in protecting liver and increasing bile secretion.

关 键 词：养肝利胆颗粒 胆囊炎 保肝 利胆 动物实验 

分 类 号：R285.5[医药卫生—中药学]