硝酸甘油在妊娠重度子痫前期的疗效观察  

The effects of nitroglycerin on the severe preeclampsia pregnancy

作　　者：张夏兰[1] 刘婵芳[1] 谢洁芬[1] 李小凤[1] 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《四川医学》2006年第8期855-856,共2页Sichuan Medical Journal

摘　　要：目的了解硝酸甘油和硫酸镁在妊娠重度子痫前期的疗效。方法将79例妊娠重度子痫前期患者随机分为硝酸甘油治疗组和硫酸镁对照组。监测两组患者治疗前后平均动脉压、血小板凝集率、24h尿蛋白定量,产科并发症和药物不良反应,以此来评价两药疗效。结果硝酸甘油降压、抑制血小板凝集作用明显,胎儿宫内窘迫、新生儿窒息及产后出血发生率低,与硫酸镁比较差异有极显著性(P<0.01),两组均可减少尿蛋白,出现头痛症状,两者比较差异不显著(P>0.05)。结论妊娠重度子痫前期患者予硝酸甘油治疗能迅速降低血压、纠正高凝状态、减少尿蛋白、降低产科并发症,不良反应较轻。值得临床进一步推广应用。Objective To fred the effects of nitroglycerin and magesium sulfate on the severe preeclampsia pregnancy. Methods All the 79 cases with severe preeclampsia pregnancy were divided into two groups：Group 1 was treated by nitroglycerin,and Group 2 was treated by magesium sulfate. To compare the effects of the medicine, the followings were recorded before and after the therapy ： the mean blood pressure, the agglutination of platelet, the proteinuria in 24 hours, the obstetric complications and the adverse effects of medicine. Results Nitroglycerin was effective in controlling the blood pressure and suppressing the high agglutination of platelet. Compared with Group 2,the rates of fetal stress,newborn asphyxia and postpartum heamrrhnge in Group 1 were low.The proteinuria was lessened in both groups. There was no significant difference in relieving the headache between the two groups. Conclusion The nitroglycerin was effective in controlling the hypertension, hssening the proteinuria, suppressing the high agglutination and reducing the complications with milde side effects when it was used to treating severe preeclampsia pregnancy.

关 键 词：妊娠 重度子痫前期 硝酸甘油 硫酸镁 

分 类 号：R714.244[医药卫生—妇产科学]