粘停宁预防外科术后腹腔粘连的实验研究  

Experimental Study on Prevention of Post-surgical Abdominal Adhesions by Medical Chitin Degraded Membrane

作　　者：沈新[1] 李孟彬[1] 王为忠[1] 施海[1] 

机构地区：[1]第四军医大学西京医院胃肠外科,陕西西安市710033

出　　处：《中国康复理论与实践》2006年第7期581-582,F0003,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨粘停宁预防术后腹腔粘连的作用和机理。方法成年纯种家兔40只构建粘连动物模型,并随机分为盲肠浆膜缺损组(A1组)和对照组(A2组)、腹壁切口组(B1组)和对照组(B2组)共4组,每组10只。将粘停宁直接贴敷到A1组和B1组可能出现粘连的手术部位,分别于术后1周和2周再次剖腹观察腹壁切口、盲肠粘连程度,并按程度分级,切取标本行HE染色,显微镜下观察。结果粘连动物模型切实可靠,A1组和B1组的粘连等级和炎症反应程度低于A2组和B2组(P<0·05)。结论术中应用粘停宁有预防术后腹腔粘连作用。Objective To investigate the effects of medical chitin degraded membrane on post-surgical abdominal adhesions. Methods Forty adult rabbits were made to form abdominal adhesions and divided randomly into four groups including group A1 and its control group A2, group B1 and its control groups B2 with 10 animals in each group. Medical chitin degraded membrane was applied in the group A and group B to the surfaces of the positions where would be adhered. All animals were cut the belly open again on the 7th, 14th postoperative day; the adhesions about incision and appendix were graded according to the severity, and took on bioscopy. Results The abdominal adhesions model was successful. The severity of adhesions and inflammatory reaction of the group A1 and group B1 was significantly milder than that of the group A2 and group B2 in every different periods （ P 〈0.05）. Conclusion The medical chitin degraded membrane used intraoperatively might have some efficacy in preventing post-surglcal abdominal adhesions.

关 键 词：外科 粘连 腹膜 粘停宁 术后并发症 家兔 

分 类 号：R619[医药卫生—外科学]