慢性再生障碍性贫血患儿血浆可溶性干细胞因子及其受体水平测定的意义  

Significance of Chronic Aplastic Anemia in Children by Determining Soluble Stem Cell Factor and Its Receptor

作　　者：孟晓晖[1] 王军[2] 原淑云[1] 冯建飞[2] 王宏[2] 

机构地区：[1]郑州市第二人民医院儿科,郑州450000 [2]郑州大学第三附属医院,郑州450052

出　　处：《实用儿科临床杂志》2006年第15期1000-1001,共2页Journal of Applied Clinical Pediatrics

基　　金：河南省医学科技创新人才工程项目资助[豫卫科(2001)9]

摘　　要：目的探讨可溶性干细胞因子(SCF)及其受体(s-kit)与儿童慢性再生障碍性贫血(CAA)发病的关系。方法利用ELISA法测定CAA患儿、正常儿童外周血浆及脐血血浆s-kit及SCF水平。结果CAA组血浆s-kit水平(13.02±5.18)μg/L低于正常儿童组(17.82±5.36)μg/L和脐血组(19.0±5.63)μg/L,CAA组血浆SCF水平(365.5±98.35)μg/L,低于正常儿童组(469.26±102.32)μg/L和脐血组(567.22±135.88)μg/L。结论CAA组血浆s-kit及SCF水平降低,提示s-kit及SCF可能在儿童CAA发病中起一定作用。Objective To investigate the function of soluble stern cell factor receptor （s-kit）and stem cell factor （SCF） in chronic aplastic anemia （CAA）. Methods ELISA assay was employed to determine the levels of s-kit and SCF in peripheral blood of CAA patients and umbilical cord blood. Results The levels of s-kit and SCF in peripheral blood of CAA patients are lower than those of normal group and umbilical cord blood group. Conclusions The decreased levels of s-kit and SCF show that s-kit and SCF may play a role in CAA mechanism. The raised levels of s-kit and SCF show that s-kit and SCF may be applied in the field of cord blood transplantation.

关 键 词：贫血 再生障碍性 慢性 干细胞因子受体 干细胞因子 功能 

分 类 号：R725.5[医药卫生—儿科]