(±)-盐酸阿朴吗啡的合成  

Synthesis of (±)-Apomorphine Hydrochloride

作　　者：倪峰[1] 商海霞[1] 严鸣乐[1] 施小新[1] 杨凯[1] 

机构地区：[1]华东理工大学化学与制药学院,上海200237

出　　处：《中国医药工业杂志》2006年第8期505-507,共3页Chinese Journal of Pharmaceuticals

基　　金：上海市教育发展基金(03SG27);国家自然科学基金(A-20172015)

摘　　要：异喹啉在氰化钾作用下和苯甲酰氯经Reissert反应、偶联反应和消除反应、与碘化钾反应成季铵盐、还原成四氢异喹啉、硝基还原、重氮化后经Pschorr环化反应制得(±)-阿朴吗啡二甲醚,再经氢溴酸脱甲基及与盐酸成盐得到(±)-盐酸阿朴吗啡,总收率31%。（±）-Apomorphine hydrochloride was synthesized from isoquinoline by Reissert reaction, coupling reaction, elimination, reaction with CH3I, reduction, diazotization and Pschorr reaction, respectively to give （±） -10,11- dimethoxyaponorphine, which was subjected to demethylation and then HCl salt formation with an overall yield of 31%.

关 键 词：阿朴吗啡 异喹啉 合成 

分 类 号：R979.9[医药卫生—药品]