老年高血压病患者血浆纤溶活性与胰岛素敏感性分析  

Correlation of plasma fibrinolytic activity and insulin sensitivity in aged hypertension patients

作　　者：朱云[1] 杨志新[1] 朱洪海[1] 邹广涛[1] 

机构地区：[1]河南医科大学第一附属医院,郑州市第二人民医院院内科

出　　处：《河南医科大学学报》1996年第4期41-43,共3页Journal of Henan Medical University

摘　　要：采用发色底物法及放免法检测了３０例老年期高血压病（ＥＨ）患者和３０例健康老年人血浆组织型纤溶酶原激活物（ｔ－ＰＡ）、纤溶酶原激活物抑制因子（ＰＡＩ）。空腹血浆胰岛素（Ｉｎ）、血糖（Ｇ）水平，分析了纤溶活性与胰岛素敏感性（ＩＳ）的相关性。结果发现：ＥＨ患者血浆ＰＡＩ活性明显高于对照组，血浆ｔ－ＰＡ活性及ＩＳ明显低于对照组；ＩＳ与ＰＡＩ显著负相关，与ｔ－ＰＡ显著正相关。提示：纤溶活性异常与胰岛素抵抗共同在高血压的发生发展中起重要作用。We measured plasma tissue-type plasminogen activator(t-PA) activity, plasminogen activator inhibitor(PAI)activity, fasting plasma insulin and glucose levels in 30 aged patients with essential hypertension(EH) and 30 control subjects. It was found that PAI activity was significantly higher, and t-PA activity and IS (insulin sensitivity)were significantly lower in the EH group than those in the control subjects. By unviariable analyses, insulin sensitivity negatively correlated with PAI activity, and positively correlated with t-PA activity in the EH group.

关 键 词：高血压 胰岛素抵抗 纤溶活性 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]