错配识别蛋白MutS的研究及应用进展  

Progress in research and application of mismatch binding protein MutS

作　　者：全智勇[1] 徐晋麟[1] 

机构地区：[1]上海交通大学生命科学技术学院,上海200240

出　　处：《生命科学》2006年第4期380-384,共5页Chinese Bulletin of Life Sciences

摘　　要：错配修复(mismatchrepairsystem,MMR)系统维护着遗传物质的稳定性。错配识别蛋白MutS是错配修复系统行使修复功能的第一个蛋白,具有识别并结合错配的能力。MutS蛋白具有特异性结合错配的特殊功能,在检测突变和SNP的研究中具有很大的应用潜力。近年来已有一些报道介绍了Muts蛋白的一些方法,虽然这些方法还有待改进,但MutS应用前景仍然十分诱人。Mismatch repair system plays a crucial role in the genetic stability of DNA. DNA mismatch binding protein MutS, is the first protein which initiate the function of MMR. MutS has the ability to recognize and binding mismatched base pair. Thus, MutS seems to be a promising tool to detect mutations and SNPs. There were some researches these years to develop techniques, using MutS as a tool to detect mutations and SNPs. These techniques still have deficiencies and more new ideas should be taken to develop these promising techniques.

关 键 词：错配修复 错配识别 MutS突变 单核苷酸多态性 

分 类 号：Q75[生物学—分子生物学]