低氧诱导因子-1α的翻译后化学修饰及其对活性的调控作用  

The post-translational chemical modification and its regulating effects on the activity of hypoxia inducible factor-1α

作　　者：康迅雷[1] 易静[1] 

机构地区：[1]上海交通大学医学院细胞生物学教研室教育部细胞分化与凋亡重点实验室,上海200025

出　　处：《生命科学》2006年第4期385-390,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30570965);上海市科委基础研究重点项目(05JC14033);上海市教委重点学科第四期(ZDXK2001)

摘　　要：低氧诱导因子-1(hypoxiainduciblefactor-1,HIF-1)是参与调节机体氧平衡的重要转录因子。作为一种蛋白质,它的主要亚基HIF-1α受到多种翻译后的化学修饰,如泛素化、羟基化、乙酰化、类泛素化、磷酸化、巯基化等的影响,从而使其蛋白的稳定性、入核以及对下游基因的促转录活性受到调节。因此,研究HIF-1α的翻译后修饰,不仅有助于我们加深对HIF-1作为一个多种疾病的治疗靶标的认识,更能为我们理解类似转录因子自身的调控提供思路。Hypoxia inducible factor-1（ HIF-1 ） is an important transcription factor in oxygen homeostasis of the organism. As a protein, its major subunit HIF-1α is subjected to a variety of the post-translational chemical modification, such as ubiquitination, hydroxylation, acetylation, sumolyation, phosphorylation, sulfhydrylation, etc. By these modifications, the stability, cytoplasmic-nuclear trafficing and transcriptional activity of HIF-1α are regulated. Therefore studies in this aspect are helpful in understanding not only HIF-1α as a therapeutic target for the diseases but also the regulation of other similar transcriptional factors.

关 键 词：低氧诱导因子-1 化学修饰 翻译后修饰 

分 类 号：Q501[生物学—生物化学]