荆芥穗化学成分的研究  

Studies on chemical constituents in spikes of Schizonepeta tenuifolia

作　　者：张援虎[1] 周岚[1] 石任兵[2] 郭亚健[2] 董玉[2] 

机构地区：[1]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [2]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2006年第15期1247-1249,共3页China Journal of Chinese Materia Medica

摘　　要：目的:研究荆芥穗Schizonepeta tenuifolia中的化学成分。方法:利用正相和反相及Sephadex LH-20柱色谱等手段进行分离纯化,MS,NMR等方法鉴定结构。结果:从荆芥穗中分离鉴定9种成分,分别为5,7-二羟基-6,4′-二甲氧基黄酮(1),5,7-二羟基-6,3′,4′-三甲氧基黄酮(2),熊果酸(3),3-羟基-4(8)-烯-p-薄荷烷-3(9)-内酯(4),5,7,4′-三羟基黄酮(5),5,4′-二羟基-7-甲氧基黄酮(6),橙皮苷(7),木犀草素(8)和胡萝卜苷(9)。结论:化合物1,2,6为首次从荆芥穗中获得。Objective： To study the chemical constituents in the spikes of Schizonepeta tenuifoila, Method：Compounds were isolated and purified with silica gel, ODS and Sephadex LH- 20 gel column chromatography, and their structures were determined by using spectroscopic analysis including MS and NMR. Result： Nine compounds were isolated and identified as 5, 7-dihydroxy-6, 4′-dimethoxyflavone （1）,5, 7-dihydroxy-6, 3′, 4′-trimethoxyflavone （2）, ursolic acid （3）, 3-hydroxy-4（8）-ene-p-menthane-3（9）-lactone （4）, 5, 7, 4′-trihydrox-yflavone （5）, 5, 4′-dihydroxy-7-methoxyflavone （6）, hesperidin （7）,luteolin （8） and daucosterol （9）.Conclusion：Compounds1, 2, 6 were first obtained from the spikes of S. tenuifolia.

关 键 词：荆芥穗 黄酮 萜类 

分 类 号：R284.1[医药卫生—中药学]