层层自组装技术在生物医用材料领域中的应用研究进展  

Progress on Layer-by-Layer Self-assemble Technique in Surface Design of Biomaterials

作　　者：林全愧[1] 计剑[1] 谭庆刚[1] 任科峰[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程学系,杭州310027

出　　处：《高分子通报》2006年第8期58-63,共6页Polymer Bulletin

基　　金：国家自然科学基金(50373036);教育部霍英东基金优选资助项目(J20040212)

摘　　要：基于聚电解质阴阳离子交替组装的层层自组装技术由于可在温和的条件下实现多种生物大分子在材料表面的固定,并通过对组装条件的控制实现多种生物功能,已成为生物医用材料表面设计的重要手段。本文对层层自组装技术在构建血液相容性界面、组织工程表面、药物控释涂层等生物医用材料领域的应用研究进行了比较系统的阐述。The Layer-by-Layer self-assembly （LbL） of polycations and polyanions into multilayers has emerged as an efficient, versatile, yet simple, technique to create biologically active surfaces. By controlling the assemble condition, bioactive molecules, such as drugs, enzymes, DNA, or proteins, may be incorporated in the muhilayer during the polyelecrolyte deposition process. The LbL technique has been recognized as an important means in designing the surfaces of the biomaterials. This paper summarized the progress on the Layer-by-Layer self-assemble technique in the design of the biointerface for cardiovascular device, tissue engineering scaffold, drug delivery systems, and so on.

关 键 词：层层自组装技术 血液相容性 细胞相容性 药物控释 抗菌 

分 类 号：R318.08[医药卫生—生物医学工程]