壳聚糖作基因载体及其改性研究进展  

Recent Progress in Chitosan and its Modification for Gene Delivery

作　　者：徐海娥[1] 闫翠娥[1] 

机构地区：[1]湖北大学化学与材料科学学院,武汉430062

出　　处：《高分子通报》2006年第8期79-87,共9页Polymer Bulletin

基　　金：武汉市青年科技晨光计划(020-093403)资助项目

摘　　要：基因载体是基因治疗的关键,病毒性基因载体在临床应用上暴露出一系列安全问题,非病毒性载体的研究成为当务之急。因其来源丰富、价廉、优良的物理化学和生物学特性,壳聚糖是当今最具潜力的非病毒性基因载体。近年来,壳聚糖作基因载体及其改性研究取得了长足的进展。本文重点从壳聚糖/基因复合物的大小、稳定性、靶向性及基因转染效率等方面概述了壳聚糖及其改性衍生物作基因载体的最新研究进展。Gene vectors are of great importance in gene therapy. Non-viral gene vectors gain most attention as viral gene vectors have shown a series of safety problems during clinical application. Chitosan is one of the best potential non-viral gene vectors because of its excellent physico-chemical and biological properties. In recent years, a lot of works have been done on chitosan and its modification for gene delivery, and valuable progresses have been achieved. In this paper, recent progress in chitosan and its modification for gene delivery are reviewed in detail in terms of size, stability, specific targeting ability and transfection efficiency of chitosan/DNA complex for different cells.

关 键 词：壳聚糖 DNA 非病毒性基因载体 改性 研究进展 

分 类 号：Q782[生物学—分子生物学] TQ931[化学工程]