重组人生长激素对败血症休克大鼠微循环功能障碍的影响  

Effects of recombinant human growth hormone on microcirculation dysfunction in septic shock rats

作　　者：曹玥[1] 徐一洲[1] 黄煌[1] 江从勋[1] 王树人[1] 黄英[1] 

机构地区：[1]四川大学华西基础医学与法医学院,四川成都610041

出　　处：《华西药学杂志》2006年第4期354-356,共3页West China Journal of Pharmaceutical Sciences

基　　金：四川省科技厅应用基础项目资助(03JY029-072-1)

摘　　要：目的观察重组人生长激素(rhGH)对败血症休克大鼠微循环功能障碍的影响。方法ipE.coli复制大鼠败血症休克模型。采用微循环观测系统及激光多普勒观测正常对照组(C组)、败血症休克组(S组)及rhGH治疗组(T组)第1、3天的肠道微循环、耳廓血流量等指标的变化情况。结果S组大鼠肠道微循环血流明显减慢甚至淤滞,血管明显扩张,血管数、管袢数及功能血管数明显减少,尤以第1天时最为明显;T组大鼠肠道微循环血液流速、血管数及功能血管数均明显高于S组,与C组比较无显著性差异。S组大鼠耳廓血流量在各时点均显著低于C组、T组水平,但T组与C组比较无明显差异。结论rhGH可明显改善败血症休克大鼠的微循环功能障碍。OBJECTIVE To observe the effects of recombinant human growth hormone （rhGH） on microcireulation dysfunction in septic shock rats. METHODS E. coli was injected intraperitoneally to produce septic shock models. Intestinal microcireulation and blood volume of ear auricle were determined dynamically by means of microcirculation observation system and laser Doppler perfusion flowmeter in control group （group C） ,septic shock group （group S） and treated group （group T） on 1 day and 3 day,respectively. RESULTS Blood flow of intestinal microcireulation obviously slowed down or stasised, blood vessel expanded evidently, numbers of vessel,loop and functional vessel were reduced significantly and more in group S on 1 d. Intestinal microvascular blood flow velocity, vessel numbers and functional vessel numbers in group T were obviously higher than those in group S and had no significant difference than those in group C. Blood volume of ear auricle in group S decreased obviously than that in beth group C and group T,while group T and group C had no significant difference. CONCLUSION rhGH treatment can obviously improve microcirculation in septic shock rats.

关 键 词：微循环 生长激素 败血症休克 

分 类 号：R331.35[医药卫生—人体生理学] R631.3[医药卫生—基础医学]