系统性红斑狼疮患者血清IL-6、TEST、E_2水平检测  

Detection of serum interleukin-6,testosterone and estradiol levels in patients with systemic lupus erythematosus

作　　者：李旭光[1] 李志清[1] 魏瑞全[1] 

机构地区：[1]解放军第323医院中心实验室,陕西西安710054

出　　处：《西北国防医学杂志》2006年第4期259-260,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨系统性红斑狼疮(SLE)患者血清中白细胞介素6(IL-6)、雌二醇(E2)和睾酮(TEST)水平及其临床意义。方法:应用ELISA法检测52例SLE患者血清IL-6水平,磁酶免法测定E2及TEST水平。结果:SLE患者血清IL-6、E2水平均显著高于正常人(P<0.01),且他们之间成正相关,并与血沉(ESR)和C反应蛋白(CRP)成正相关。TEST水平与对照组相比明显下降。结论:IL-6、E2可能参与SLE的发病及病理、免疫功能变化过程,IL-6、E2水平检测有助于SLE患者病情活动的判断及药物疗效的观察。Objective： To detect the levels of serum interleukin - 6 （ IL - 6）, testosterone （TEST） and estradiol （ E2 ） in patients with systemic lupus erythematosus （ SLE）, and explore its clinical significance . Methods： The level of serum IL -6 was measured by ELISA method in 52 patients with SLE. The levels of serum E2 and TEST were detected by magnetic enzyme immunoassay. Results： The levels of IL -6 and E2 in patients with SLE were markedly higher than those in normal group （P 〈0.01 ）. There was a positive correlation between IL -6, E2, ESR and CRP. The level of TEST was lower than that in normal group. Conclusion： IL -6 and E2 may be involved in the development of SLE and related to the activity of SLE. Detection of serum IL - 6 and E2 levels may be useful for observing the status of the disease and the therapeutic efficacy.

关 键 词：系统性红斑狼疮 白细胞介素6 雌二醇 睾酮 

分 类 号：R593.241[医药卫生—内科学]