迟发性维生素K缺乏性颅内出血患儿血浆心钠素与低钠血症的关系  

Relationship between atrial natriuretic peptide and hyponatremia in delayed vitamin K deficiency children with intracranial hemorrhage

作　　者：方琦[1] 王优[2] 赵革灵[1] 罗学忠[1] 

机构地区：[1]广东医学院附属医院神经外科,广东湛江524001 [2]广东医学院附属医院儿科,广东湛江524001

出　　处：《中国小儿急救医学》2006年第4期329-331,共3页Chinese Pediatric Emergency Medicine

摘　　要：目的探讨迟发性维生素K缺乏性颅内出血患儿心钠素(ANP)水平变化与低钠血症的关系及其临床意义。方法应用放射免疫分析技术检测108例颅内出血患儿不同病程的血浆ANP水平,同时检测血清钠的含量,选取25例健康同龄儿作为对照。结果(1)颅内出血急性期血浆ANP水平均高于对照组(P<0·05);昏迷组患儿ANP升高更明显(P<0·01);(2)颅内出血患儿血浆ANP与血清钠水平呈负相关(γ=-0·748,P<0·05)。结论(1)迟发性维生素K缺乏性颅内出血患儿血浆ANP水平反映脑损伤严重程度;(2)ANP参与迟发性维生素K缺乏性颅内出血患儿低钠血症的形成过程。Objective To investigate the clinical significance of atrial natriuretic peptide （ANP） in delayed vitamin K deficiency children with intracranial hemorrhage. Methods The plasma ANP levels in 108 delayed vitamin K deficiency children with intraeranial hemorrhage and 25 controls were measured by radioimmunoassay. Meanwhile, the serum sodium was examined. Results （ 1 ） The plasma ANP level of patients with acute intracranial hemorrhage was higher than that of control group （P 〈 0.05） and comatose group showed even higher plasma ANP level. （2） The plasma ANP levels were negatively correlated with the serum sodium （ r = - 0. 748, P 〈 0.05 ）. Conclusion （ 1 ） The ANP level of plasma in patients with intracranial hemorrhage is related to the severity of brain damage. （2） ANP may be invloved in the pathogenesis of hyponatremia.

关 键 词：迟发性维生素K缺乏 颅内出血 心钠素 低钠血症 

分 类 号：R723[医药卫生—儿科]