新型Ⅲ类抗心律失常药物尼非卡兰对心房及肺静脉组织动作电位的影响  

The Effect of A Novel Class Ⅲ Antiarrhythmic Drug-Nifekalant On Action Potential of Atrium And Pulmonary Vein

作　　者：韩昊[1] 方丕华[1] 刘秀兰[2] 杨新春[2] 王瑶[3] 王亚平[1] 马坚[1] 

机构地区：[1]中国医学科学院阜外心血管病医院,北京100037 [2]北京市朝阳医院心脏中心,北京100020 [3]北京师范大学,北京100875

出　　处：《中国实用内科杂志：临床前沿版》2006年第8期1269-1271,共3页

摘　　要：目的研究尼非卡兰对心房及肺静脉组织动作电位的影响,探讨尼非卡兰在房性心律失常中的作用。方法2006年3月至4月,阜外心血管病医院电生理中心及北京市朝阳医院心脏中心从15只大耳白兔取右心房、左心房和肺静脉组织制成0.5cm×1.5cm组织条,用2倍阈强度,脉宽3ms刺激引发动作电位,采用标准玻璃微电极技术记录心房及肺静脉肌袖组织动作电位,用分级递增刺激和程序刺激测定各部位组织在基础条件下的不应期。用质量浓度为2.13mg/L的尼非卡兰的台氏液灌流组织条15min后,采用同样方法引发动作电位和测定不应期,比较用尼非卡兰前后动作电位时相和不应期的变化。结果尼非卡兰灌流后,左心房APD90由(51±16)ms延长到(78±33)ms(P<0.05),右心房APD90由(53±12)ms延长到(71±13)ms(P<0.05,),肺静脉肌袖APD90由(59±7)ms延长到(98±11)ms(P<0.001,),ERP由(102±8)ms延长到(118±13)ms(P<0.05)。结论尼非卡兰的延长心房和肺静脉肌袖组织动作电位时相及不应期的电药理作用可能是其治疗房性心律失常的基础。Objective To investigate the effect of Nifekalant on action potential of atrium and pulmonary vein and the possible clinical efficacy of Nifekalant against atrial tachyarrhythmias, Methods left and right atrium and pulmonary vein removed from 15 white rabbits were made into tissue preparations （0. 5 cm × 1. 5 cm）, Action potential was induced by electric stimulation with twofold capture threshold and recorded by standard glass microelectrode technique. Effective retractory periods of left and right atrial and pulmonary vein tissues were measured with burst and programmed stimulation. The Action potentials and effective refractory periods of various tissues were compared between before and after irrigation of Tyrodes fluid containing Nifekalant of 2. 13 mg/L. Results After irrigation of Tyrodes fluid containing Nifekalant, APD90 was prolonged [ （51 ±16） ms vs （78 ±33） ms, P〈0.05]in the left atrium, [ （53 ±12） ms vs （71 ±13） ms, P 〈0.05] in the right atrium and [ （59 ±7） ms vs （98±11） ms, P 〈0.001] in pulmonary vein, ERP was prolonged [ （102 ±8） ms vs （118± 13） ms, P 〈0. 05] significantly in pulmonary vein. Conclusion The electropharmaceutical property of Nifekalant may underlie the clinical efficacy of the drug against atrial tachyarrhythmias.

关 键 词：尼非卡兰 肺静脉 动作电位 兔 

分 类 号：R5[医药卫生—内科学]