三例氨基糖甙类抗生素致聋患者的线粒体DNA测序分析  

Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness

作　　者：张丽珊[1] 张志平[1] 周晓雷[1] 黄鹰[1] 奚荣楠 

机构地区：[1]南京铁道医学院生物学教研室,南京210009 [2]江苏省泗洪县聋哑学校,泗洪221900

出　　处：《遗传》1996年第6期3-5,共3页Hereditas（Beijing)

基　　金：国家自然科学基金

摘　　要：应用PCR扩增产物直接对3名氨基糖甙类抗生素致聋患者的线粒体DNA进行序列分析，结果表明，他们的线粒体DNA均存在第1555位核苷酸A－G的突变．因此认为该突变是人体对氨基精甙类抗生素致聋遗传易感性的分子基础，与氨基糖甙类抗生素共同作用造成耳聋。The mitochondria DNAs (mtDNAs) of thrce patients with AAID were analysed using the method of direct sequeneing of their PCR produets. The results showed that all their mtDNAs had an A-G mutation at nucleotides 1 555. It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in coopcration with Aminoglycoside Antibiotics results in deafness.

关 键 词：药源性疾病 线粒体DNA 氨基糖甙类 抗生素 耳聋 

分 类 号：R595.302[医药卫生—内科学] R978.12[医药卫生—临床医学]