细胞周期与细胞凋亡  

Cell Cycle and Apoptosis

作　　者：周明华[1] 陈思颖[1] 李美芳[1] 吴玺印[1] 

机构地区：[1]香港大学医学院解剖学系

出　　处：《生理科学进展》1996年第4期319-323,共5页Progress in Physiological Sciences

基　　金：GrowthFactor公司资助

摘　　要：从海洋生物胚胎细胞到哺乳动物的细胞周期，主要是在其细胞周期基因产物周期素及ｐ３４（ｃｄｃ２）的调控下启动、运行和脱出周期的；某些原癌基因或抑癌基因的产物如ｐ５３、ｐＲＢ也直接调控着细胞周期。但是，促进细胞有丝分裂的ｐ３４（ｃｄｃ２）也能够启动某些类型细胞的凋亡。因此，细胞周期正常调控成分的突变，将使细胞凋亡，或使细胞增殖失控。The progression of cell cycle in embryonic cells from oceanic bionts to mammalians is initiated, promoted and terminated under the regulation of cell cycle gene products,named cyclins,and a p34 (cdc 2 ). Besides, oncogene(proto-oncogene)products such as p53 and pRB also directly regulate the progression of cell cycle, Howeverf the p34(cdc 2)which promotes the mitotic cell division also initiates the apoptosis of certain cells.Therefore, mutations of genes that regulate the normal progression of cell cycle would cause cells in the cell cycle undergoing either apoptosis or uncontrollable proliferation.

关 键 词：细胞周期 细胞 细胞凋亡 

分 类 号：Q28[生物学—细胞生物学] R329.28[医药卫生—人体解剖和组织胚胎学]