丁香酚对脂多糖发热大鼠血浆及脑脊液中精氨酸加压素含量的影响  

EFFECTS OF EUGENOL ON ARGININE VASOPRESSIN CONTENT IN PLASMA AND CSF IN FEVERISH RATS

作　　者：张文彬[1] 叶红[2] 王晓斌[2] 

机构地区：[1]承德医学院附属医院,河北承德067000 [2]承德医学院临床技能学教研室

出　　处：《承德医学院学报》2006年第3期227-229,共3页Journal of Chengde Medical University

摘　　要：目的:探讨丁香酚抑制脂多糖所致发热的机制。方法:建立大鼠脂多糖性发热模型,观察丁香酚对大鼠直肠温度的影响,放免法测定大鼠血浆及脑脊液中精氨酸加压素(AVP)含量的变化。结果:腹腔注射脂多糖溶液后大鼠直肠温度明显升高(P<0．01),血浆及脑脊液中AVP的含量也明显升高(P< 0．05);丁香酚能明显抑制脂多糖所致大鼠发热反应(P<0．01),同时血浆及脑脊液中AVP含量也进一步增加(P<0．05)。结论:丁香酚通过增加体内AVP的含量而发挥解热作用。Objective：To study the mechanisms of eugenol suppressing LPS-induced fever in rats. Methods： Feverish rat model was established by intraperitoneal injection （i. p. ） of LPS. The effects of eugenol on rectal temperature of the rats were observed, and the changes of arginine vasopressin （AVP） content in plasma and CSF were determined with radioimmunoassay. Results： Intraperitoneal injection of LPS significantly increased rectal temperature （P〈0.01）, AVP content in both plasma and CSF （ P 〈 0.05）. Eugenol had markedly inhibitory effects on the LPS-induced fever in rats （P〈0.01）, and AVP content in both plasma and CSF increased significantly （P〈0.05） after eugenol administration. Conclusions： Eugenol may have antipyretic effects by decreasing AVP content.

关 键 词：丁香酚 脂多糖 发热 精氨酸加压素 

分 类 号：R285.5[医药卫生—中药学]