雌激素对大鼠部分肝缺血再灌注损伤的影响  

EFFECTS OF ESTROGEN ON REDUCED-SIZE LIVER ISCHEMIA REPERFUSION INJURY IN RATS

作　　者：闫凤霞[1] 刘艳华[1] 王艳辉[1] 孙阁[1] 袁亚非[1] 

机构地区：[1]承德医学院机能实验学教研室,河北承德067000

出　　处：《承德医学院学报》2006年第3期229-231,共3页Journal of Chengde Medical University

摘　　要：目的:观察雌激素在大鼠部分肝缺血再灌注损伤中的作用。方法:60只SD大鼠随机分为雌性组(F组)、雄性组(M组)、雌性卵巢切除组(O组)、雄性雌二醇组(E2组),每组15只,分别研究雌激素在大鼠部分肝缺血再灌注损伤中的作用,以血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(AKP)水平作为评定肝损伤的指标。结果:F组的ALT、AST、AKP水平明显低于M组及O组(P< 0．05);E2组的ALT、AST、AKP水平明显低于M组及O组(P<0．05)。结论:雌激素对大鼠部分肝缺血再灌注损伤具有明显的保护作用。Objective：To study the effects of estrogen on reduced-size liver isehemia reperfusion injury in rats. Methods： 60 SD rats were divided into female group （F group）, male group （M group）, ovarieetomy group （O group） and estrogen group （E2 group） at random. All the rats were made reduced-size liver isehemia reperfusion rats model, and ALT, AST, AKP content in serum were applied to evaluate the hepatic function in isehemia reperfusion injury. Results： The ALT, AST, AKP content in serum of F group were obviously lower than that of M group and O group （P〈0. 05）. The ALT, AST, AKP content in serum of E2 group were obviously lower than that of M group and O group （P〈0.05）. Conclusions： Estrogen has significant protection for liver in reduced-size liver ischemia reperfusion injury.

关 键 词：部分肝 缺血再灌注 雌激素 

分 类 号：R333.4[医药卫生—人体生理学]