血府逐瘀颗粒对急性心肌梗死犬的保护作用  

Protective effect of xfzhyg on myocardium in dogs with experimental myocardial infarction

作　　者：王秋静[1] 崔新明[1] 吕文伟[1] 路航[2] 崔璐[3] 

机构地区：[1]吉林大学新民校区基础医学院,吉林长春130021 [2]吉林大学化学院教学中心,吉林长春130021 [3]吉林大学生物与农业工程学院2004级生物工程专业,学生吉林长春130025

出　　处：《中国现代医学杂志》2006年第15期2287-2289,2293,共4页China Journal of Modern Medicine

摘　　要：目的观察血府逐瘀颗粒对急性心肌梗死犬的保护作用。方法将24只杂种犬,随机分为4组,第1组为生理盐水(Control)对照组,第2组为阳性药血府逐瘀口服液(xfzhyo)对照组,第3,4组为血府逐瘀颗粒(xfzhyg)小,大剂量组。采用麻醉开胸犬,结扎冠状动脉左前降支,复制犬急性心肌梗死模型,测定心肌梗死面积(MIS)、血清心肌三酶以及心肌细胞超微结构的改变。结果血府逐瘀颗粒均可缩小MIS,降低心肌三酶的活性,减轻缺血对心肌细胞超微结构的损伤程度。结论血府逐瘀颗粒对急性心肌梗死犬的心肌具有一定的保护作用。[Objective] To observe the protective effects of xfzhyg on acute myocardial infarction in dogs. [Methods] Twenty-four dogs were devidod at random into four groups： control group; xfzhyo group; low-dose xfzhyg group; high-dose xfzhyg group. The myocardial infarction size, the changes of myocardial enzymes（AST,CPK,LDH） and the changes of the myocardial ultrastructure were determined lay using the acute myocardial infarction models of ligation of left anterior descending branch （LAD） in the anaesthetized open-chest dogs. [Results] The myocardial infarction size, the activity of blood serum AST, CPK, LDH and the ultrastructral injuries were decreased in acute myocardial infarction dogs treated with xfzhyg. [Conclusions] Xfzhyg has the protective effects on acute myocardial infarction in dogs.

关 键 词：血府逐瘀颗粒 心肌梗死 心肌酶 超微结构 

分 类 号：R972[医药卫生—药品]