过敏性紫癜与幽门螺杆菌感染关系的初步探讨  

Exploring the relationship between Henoch-Schonlein purpura and Helicobacter pylori infection

作　　者：严加林[1] 张明亮[2] 卢小刚[1] 郭田章[1] 

机构地区：[1]南华大学附属第二医院皮肤性病科,湖南衡阳421001 [2]南华大学附属第二医院消化内科,湖南衡阳421001

出　　处：《中国现代医学杂志》2006年第15期2374-2376,共3页China Journal of Modern Medicine

摘　　要：目的探讨幽门螺杆菌感染与过敏性紫癜的关系以指导治疗。方法对18例过敏性紫癜患者进行胃镜检查及Hp检测,对其中15例Hp感染阳性患者进行Hp根治并观察其疗效。结果18例患者均有胃十二指肠黏膜改变,伴胃肠道症状患者的胃肠黏膜损害较严重。Hp感染阳性率83.3%(15/18),其中伴胃肠道症状患者Hp感染阳性率100%(5/5),不伴胃肠道症状患者Hp感染阳性率76.9%(10/13),Hp感染阳性患者经Hp根治后临床症状消退迅速,随访6个月～2年半,7例反复发作慢性患者仅1例复发。结论Hp感染可能是HSP发病的诱发因素之一或是加重胃肠道症状的原因,对伴明显胃肠道症状或反复发作的慢性过敏性紫癜患者可考虑进行Hp检测,Hp感染阳性患者可同时给以Hp根治以缓解胃肠道症状并减少复发。[Objective] To explore the relationship between Henoch-Sehonlein purpura and Helicobacter pylori infeetion and to direet therapy. [Methods] Fibre gastroseope, Helieobaeter pylori（Hp） deteetion and biopsy were employed to 18 patients of Henoeh -Sehonlein purpura. Then Hp-positive patients were treated with eradieation therapy. [Result] The gastrie and duodenal mueosa were involved in all 18 patients and the involvements were more serious in patients aeeompanied by abdominal pain than those non-aeeompanied by abdominal pain. The Hp-positive rate was 83,8%（15/18）. The Hp-positive rate was 100% （5/5） in patients aeeompanied by abdominal pain and 76.9%（10/13） in those non-aeeompanied by abdominal pain, The symptoms of skin rash and abdominal pain in 17 patients disappeared rapidly after Hp eradieation therapy, Only 1/7 relapse patient reeurred after 6 -30 months followed-up. [Conclusion] Hp infeetion may be one of triggering events whieh eaused HSP reeurfing or the eause of aggravating abdominal symptoms. Hp examined may be eonsidered to HSP patients aeeompanied by severe abdominal symptoms and relapse patients. Hp eradieation therapy may relieve abdominal pain and fall reeurring for Hp-positive patients.

关 键 词：过敏性紫癜 幽门螺杆菌 

分 类 号：R554.6[医药卫生—血液循环系统疾病]